133391-51-2 Usage
Main Properties
1. Chemical Name: 2′-(pentafluoroethyl)acetophenone
2. Alternative Name: Pentafluoroethylacetophenone
3. Molecular Formula: \textC10\textH9\textF5\textO
4. Physical State: Clear, colorless liquid
5. Odor: Distinctive fruity odor
6. Common Uses: Building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds
7. Versatility: Acts as a versatile intermediate capable of undergoing various reactions
8. Reactivity: Exhibits reactivity in different chemical transformations
9. Stability: High stability under appropriate conditions
10. Value: Valuable tool in organic chemistry research and industrial applications
Chemical Structure
Consists of a benzene ring substituted with a pentafluoroethyl group and an acetyl group.
Synthesis
Produced through specific chemical reactions involving precursors and catalysts.
Functional Groups
Contains functional groups including an aromatic ring, an acetyl group ( -\textCOCH3 ), and a pentafluoroethyl group ( -\textCF2\textCF3 ).
Reaction Types
Undergoes reactions such as acylation, nucleophilic substitution, and addition reactions due to the presence of functional groups.
Applications
Used in the pharmaceutical industry for drug synthesis, in agrochemicals for pesticide production, and in various organic synthesis processes.
Handling Considerations
Requires careful handling due to potential health and environmental risks.
Safety Precautions
Proper ventilation, personal protective equipment (PPE), and adherence to handling guidelines are necessary.
Environmental Impact
May pose risks if released into the environment due to its chemical properties.
Overall, 2′-(pentafluoroethyl)acetophenone is a versatile compound with significant utility in organic chemistry, but caution must be exercised in its handling to mitigate potential risks.
Check Digit Verification of cas no
The CAS Registry Mumber 133391-51-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,3,9 and 1 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133391-51:
(8*1)+(7*3)+(6*3)+(5*3)+(4*9)+(3*1)+(2*5)+(1*1)=112
112 % 10 = 2
So 133391-51-2 is a valid CAS Registry Number.
133391-51-2Relevant academic research and scientific papers
"ligandless" Pentafluoroethylation of Unactivated (Hetero)aryl and Alkenyl Halides Enabled by the Controlled Self-Condensation of TMSCF3-Derived CuCF3
Mestre, Jordi,Castillón, Sergio,Boutureira, Omar
supporting information, p. 15087 - 15097 (2019/11/03)
Pentafluoroethylation of unactivated C(sp2)-X bonds (X = I, Br) using a storable, "ligandless" CuC2F5 reagent prepared by controlled self-condensation of ready available TMSCF3-derived CuCF3 has been
THE TRIFLUOROMETHYLATION OF CHLOROAROMATICS USING THE COPPER-CF2Br2-DIALKYLAMIDE REACTION SYSTEM
Clark, James H.,Denness, James E.,McClinton, Martin A.,Wynd, Andrew J.
, p. 411 - 426 (2007/10/02)
The in situ generation of CuCF3 from the reaction of copper, dibromodifluoromethane and either N,N-dimethylformamide or N,N-dimethylacetamide (Burton's reagent) has been used for the direct substitution of chlorine by CF3 in a number of aromatic substrates.Particular attention has been paid to the effects of ring substituents on the efficiency of reaction.
