133400-94-9Relevant academic research and scientific papers
Discovery of Mitochondrial Transcription Inhibitors Active in Pancreatic Cancer Cells
Chen, Wenmin,Hu, Shuai,Mao, Shuai,Xu, Yibin,Guo, Hui,Li, Haoxi,Paulsen, Michelle T.,Chen, Xinde,Ljungman, Mats,Neamati, Nouri
, p. 2029 - 2039 (2020)
Mitochondrial dysfunction is a hallmark of cancer cells and targeting cancer mitochondria has emerged as a promising anti-cancer therapy. Previously, we repurposed chlorambucil by conjugating it to a mitochondrial targeting triphenylphosphonium (TPP) grou
