97545-51-2Relevant articles and documents
An efficient synthesis of ([18F]fluoropropyl)quinoline-5,8- diones by rapid radiofluorination-oxidative demethylation
Sachin, Kalme,Jeong, Hwan-Jeong,Lim, Seok Tae,Sohn, Myung-Hee,Chi, Dae Yoon,Kim, Dong Wook
, p. 1763 - 1767 (2011)
Since many molecules bearing quinoline-5,8-dione or fused 1,4-quinone moieties possess a wide spectrum of biological activities, efficient methods for incorporation of fluorine-18 (F-18) into quinoline-5,8-diones have received considerable attention in po
Synthesis and biological activities of truncated acridone: Structure-activity relationship studies of cytotoxic 5-hydroxy-4-quinolone
Chun, Moon Woo,Olmstead, Kay Kim,Choi, Yong Suck,Lee, Chong Ock,Lee, Chong-Kyo,Kim, Joong Hyup,Lee, Jeewoo
, p. 789 - 792 (1997)
A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor and antiherpes activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activi
Discovery of Mitochondrial Transcription Inhibitors Active in Pancreatic Cancer Cells
Chen, Wenmin,Hu, Shuai,Mao, Shuai,Xu, Yibin,Guo, Hui,Li, Haoxi,Paulsen, Michelle T.,Chen, Xinde,Ljungman, Mats,Neamati, Nouri
, p. 2029 - 2039 (2020/09/11)
Mitochondrial dysfunction is a hallmark of cancer cells and targeting cancer mitochondria has emerged as a promising anti-cancer therapy. Previously, we repurposed chlorambucil by conjugating it to a mitochondrial targeting triphenylphosphonium (TPP) grou
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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Page/Page column 93, (2009/06/27)
Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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Page/Page column 102-103, (2009/06/27)
Compounds of formula (I): wherein c, X, Y, R2, R4 and R5 are defined herein, are useful as inhibitors of HIV replication.
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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Page/Page column 100-101, (2009/06/27)
The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection
Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B
Keinan, Shahar,Paquette, William D.,Skoko, John J.,Beratan, David N.,Yang, Weitao,Shinde, Sunita,Johnston, Paul A.,Lazo, John S.,Wipf, Peter
experimental part, p. 3256 - 3263 (2009/02/05)
Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E1/2.
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
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Page/Page column 12, (2008/06/13)
Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and at least one bicyclic 6-6 (0:1, 0:2, 1:1, 1:2) aza heteroaromatic keratin dyeing compound with one or two N-oxides. A method for oxidative dyeing of kerat
SYNTHESIS OF 4(1H)-QUINOLONES BY THERMOLYSIS OF ARYLAMINOMETHYLENE MELDRUM'S ACID DERIVATIVES
Cassis, Raul,Tapia, Ricardo,Valderrama, Jaime A.
, p. 125 - 134 (2007/10/02)
A series of 4(1H)-quinolones were obtained from Meldrum's acid and arylamines in two steps.