133407-14-4

Upstream product

• 76622-52-1 rac-isopropylmethylphenylsilane 

Downstream Products

• 1273594-99-2 rac-3-isopropylmethylphenylsilyl-1-methylindole 
• 1273594-97-0 C₂₆H₃₈OSi 
• 1273594-98-1 C₂₆H₃₈OSi 

Relevant academic research and scientific papers

Cooperative catalytic activation of Si-H bonds by a polar Ru-S bond: Regioselective low-temperature c-h silylation of indoles under neutral conditions by a Friedel-crafts mechanism

Merging cooperative Si-H bond activation and electrophilic aromatic substitution paves the way for C-3-selective indole C-H functionalization under electronic and not conventional steric control. The Si-H bond is heterolytically split by the Ru-S bond of a coordinatively unsaturated cationic ruthenium(II) complex, forming a sulfur-stabilized silicon electrophile. The Wheland intermediate of the subsequent Friedel-Crafts-type process is assumed to be deprotonated by the sulfur atom, no added base required. The overall catalysis proceeds without solvent at low temperature, only liberating dihydrogen.

Silylating agent

The present invention is a silylating agent of formula where R is an isopropyl group, R1 is a monovalent hydrocarbon group having 2 to 6 carbon atoms, and X is a chlorine atom or bromine atom. The silylating agent of the present invention provide silylation product which is much more stable than the silylation product obtained with trimethylchlorosilane, and its protective group is as stable as the silylation product obtained from t-butyldimethylchlorosilane. Moreover, the present described silylating agents are characterized by an easier desilylation than the t-butyldimethylsilyl group.