1334106-79-4

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 90213-66-4 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 1334106-87-4 2-(4-ethoxyphenyl)-4-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1334106-91-0 2-(4-ethoxyphenyl)-4-(4-methoxyphenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidine 
• 1334106-81-8 tert-butyl 2-chloro-4-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate 
• 1334106-84-1 tert-butyl 2-(4-ethoxyphenyl)-4-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate 
• 1352567-79-3 2-chloro-4-(4-methoxyphenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-anilino-4-substituted-7H- pyrrolopyrimidines as PDK1 inhibitors

PDK1, a biological target that has attracted a large amount of attention recently, is responsible for the positive regulation of the PI3K/Akt pathway that is often activated in a large number of human cancers. A series of second-generation 2-anilino-4-substituted-7H-pyrrolopyrimidines were synthesised by installation of various functions at the 4-position of the 7H-pyrrolopyrimidine scaffold. All compounds were screened against the isolated PDK1 enzyme and dose response analysis was obtained on the best compounds of the series. Crown Copyright

New fused pyrroles with rA1/A2A antagonistic activity as potential therapeutics for neurodegenerative disorders

In a pilot study, eleven pyrrolopyridine and pyrrolopyrimidine derivatives (specifically, 7-azaindole and 7-deazapurine derivatives) were synthesised by Suzuki cross-coupling reactions and evaluated via radioligand binding assays as potential adenosine re

Synthesis of 4-aryl-, 2,4-diaryl- and 2,4,7-triarylpyrrolo[2,3-d] pyrimidines by a combination of the Suzuki cross-coupling and N-arylation reactions

A simple and facile synthesis of novel 4-aryl-2-chloro-, 2,4-diaryl- and 2,4,7-triarylpyrrolo[2,3-d]pyrimidines with various aryl and heteroaryl assemblies in the heterocyclic framework by a combination of Suzuki cross-coupling and N-arylation reactions of 2,4-dichloropyrrolo[2,3-d]pyrimidine with arylboronic acids and haloarenes are described. A majority of the synthesized compounds were found to emit in a near UV-blue spectral range with fluorescence quantum yields up to 67%. The impact of aryl groups attached to the pyrrole ring of pyrrolopyrimidine derivatives on optical properties is discussed.