1334173-62-4Relevant articles and documents
Asymmetric total synthesis of a pentacyclic lycopodium alkaloid: Huperzine-Q
Nakayama, Atsushi,Kogure, Noriyuki,Kitajima, Mariko,Takayama, Hiromitsu
, p. 8025 - 8028 (2011/10/18)
Right on Q: The first asymmetric total synthesis of (-)-huperzine-Q, which possesses six stereogenic centers and a spiroaminal moiety, has been achieved in 19 steps and 16.4 % overall yield. This synthesis involved a novel stereoselective Pauson-Khand reaction, a vinyl Claisen rearrangement, and a biomimetic spiroaminal formation. TBDPS=tert-butyldiphenylsilyl.