1334224-68-8

Basic information

• Product Name: 6-methyl-4-[4-(trifluoromethoxy)phenyl]-2(2H)-pyranone
• Synonyms: 6-methyl-4-[4-(trifluoromethoxy)phenyl]-2(2H)-pyranone
• CAS NO: 1334224-68-8
• Molecular Weight: 254.208
• Mol File: 1334224-68-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-methyl-4-[4-(trifluoromethoxy)phenyl]-2(2H)-pyranone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-4-[4-(trifluoromethoxy)phenyl]-2(2H)-pyranone(1334224-68-8)
• EPA Substance Registry System: 6-methyl-4-[4-(trifluoromethoxy)phenyl]-2(2H)-pyranone(1334224-68-8)

Safety Data

• Hazardous Substances Data: 1334224-68-8(Hazardous Substances Data)

Upstream product

• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 132559-91-2 4-bromo-6-methyl-2H-pyran-2-one 
• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 31913-41-4 6-methyl-4-tosyloxy-2(2H)-pyranone 

Relevant articles and documents

Catalyst- And additive-free Baeyer-Villiger-type oxidation of α-iodocyclopentenones to α-pyrones: Using air as the oxidant

An efficient synthetic approach for the synthesis of α-pyrones via Baeyer-Villiger-type oxidation of α-iodocyclopentenones through a catalyst- and additive-free system using air as an environmentally benign oxidant is described. The reaction exhibits excellent functional group compatibility and provides a simple and efficient protocol for the construction of highly functionalized α-pyrones under mild reaction conditions.

Rapid access to 4-substituted-pyrones and 2(5H)-furanones via a palladium-catalyzed C-OH bond activation

An efficient palladium-catalyzed cross-coupling reaction of 4-hydroxy-pyrone or 4-hydroxy-2(5H)-furanone with arylboronic acid is described, which affords the 4-substituted-pyrones and 2(5H)-furanones in good yields. This transformation proceeds through a C-OH bond activation under mild conditions.