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3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid, also known as Hydroxy-PEG2-acid sodium salt, is a PEG (polyethylene glycol) linker containing a hydroxyl group with a terminal carboxylic acid in its sodium salt form. This molecule is characterized by its stability in the sodium salt form, which prevents the reaction of the hydroxyl group with the PEG-COOH group that would otherwise lead to polymer formation. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amine groups in the presence of activators such as EDC or HATU. Additionally, the hydrophilic PEG spacer enhances solubility in aqueous media, while the hydroxyl group provides the possibility for further derivatization or replacement with other reactive functional groups.

1334286-77-9

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1334286-77-9 Usage

Uses

Used in Pharmaceutical Industry:
3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid is used as a versatile building block for the synthesis of various pharmaceutical compounds. Its ability to form stable amide bonds with primary amine groups makes it a valuable component in the development of drug conjugates, prodrugs, and other bioactive molecules.
Used in Drug Delivery Systems:
In the field of drug delivery, 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid serves as a key component in the design of targeted drug delivery systems. The hydrophilic PEG spacer and the reactive terminal carboxylic acid enable the creation of nanoparticles, liposomes, and other carriers that can improve the solubility, bioavailability, and targeted delivery of therapeutic agents.
Used in Bioconjugation and Molecular Assembly:
3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid is utilized as a linking agent in bioconjugation and molecular assembly processes. The hydroxyl group allows for further derivatization or replacement with other reactive functional groups, enabling the attachment of various biomolecules, such as proteins, peptides, or nucleic acids, to create multifunctional conjugates or assemblies with tailored properties and applications.
Used in Diagnostics and Imaging:
In the diagnostics and imaging sector, 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid can be employed as a component in the development of contrast agents or probes for various imaging modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), or optical imaging. The hydrophilic PEG spacer and the ability to form stable amide bonds can contribute to the enhancement of the stability, solubility, and biocompatibility of these imaging agents.
Used in Material Science:
3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid can also find applications in material science, particularly in the development of hydrogels, polymers, and other biomaterials. The hydrophilic PEG spacer and the reactive terminal carboxylic acid can be exploited to create materials with specific properties, such as controlled drug release, tunable mechanical properties, or enhanced biocompatibility for various biomedical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1334286-77-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,4,2,8 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1334286-77:
(9*1)+(8*3)+(7*3)+(6*4)+(5*2)+(4*8)+(3*6)+(2*7)+(1*7)=159
159 % 10 = 9
So 1334286-77-9 is a valid CAS Registry Number.

1334286-77-9Upstream product

1334286-77-9Downstream Products

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