1334288-00-4

Upstream product

• 7519-88-2 2,4,6-tris-(2-naphthyl)boroxine 
• 99333-34-3 N-(2,2,2-trifluoroethylidene)-4-methoxyaniline 
• 1800-42-6 2-naphthyl trifluoromethyl ketone 
• 104-94-9 4-methoxy-aniline 
• 14796-89-5 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline 
• 1334287-92-1 4-methoxy-N-(2,2,2-trifluoro-1-(naphthalen-2-yl)ethylidene)aniline 

Downstream Products

• 843608-58-2 2,2,2-trifluoro-1-naphthalen-2-yl-ethylamine 

Relevant academic research and scientific papers

Palladium(II)-Catalyzed Enantioselective Synthesis of α-(Trifluoromethyl)arylmethylamines

We describe a method for the synthesis of α-(trifluoromethyl)arylmethylamines that consists of the palladium(II)-catalyzed addition of arylboroxines to imines derived from trifluoroacetaldehyde. Palladium acetate is used as a catalyst with electron-neutral or electron-rich arylboroxines, and it was found that addition of an ammonium or silver salt was crucial to promote the reaction of electron-poor boroxines. With (S)-t-Bu-PyOX as the chiral ligand, this method delivers a variety of α-trifluoromethylated amines in 57-91% yield and with greater than 92% ee in most cases.

Chiral phosphoric acid catalyzed transfer hydrogenation: Facile synthetic access to highly optically active trifluoromethylated amines

Amines to an end: Highly optically active α-CF3- functionalized amines can be obtained using metal-free reaction conditions. The method involves the transfer hydrogenation of CF3-substituted ketimines catalyzed by 1 and reductive ami