843608-58-2 Usage
Uses
Used in Organic Synthesis:
(1R)-2,2,2-TRIFLUORO-1-(2-NAPHTHYL)ETHYLAMINE is used as a chiral auxiliary in organic synthesis for the creation of optically pure compounds. Its unique structure allows for the production of enantiomerically pure substances, which are essential in various chemical reactions and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (1R)-2,2,2-TRIFLUORO-1-(2-NAPHTHYL)ETHYLAMINE is used as a building block or intermediate in the development of new drugs. Its chiral nature and potential in asymmetric synthesis make it a valuable component in the synthesis of biologically active molecules with specific therapeutic effects.
Used in Agrochemical Industry:
(1R)-2,2,2-TRIFLUORO-1-(2-NAPHTHYL)ETHYLAMINE also finds application in the agrochemical industry, where it is used in the synthesis of chiral pesticides and other agrochemical products. The ability to produce optically pure compounds ensures the desired biological activity and selectivity of these products.
Used in Advanced Materials Synthesis:
(1R)-2,2,2-TRIFLUORO-1-(2-NAPHTHYL)ETHYLAMINE is utilized in the synthesis of advanced materials, where its unique properties can contribute to the development of new materials with specific characteristics, such as improved stability, reactivity, or selectivity.
It is crucial to handle (1R)-2,2,2-TRIFLUORO-1-(2-NAPHTHYL)ETHYLAMINE with care and follow proper safety protocols due to its potentially hazardous nature.
Check Digit Verification of cas no
The CAS Registry Mumber 843608-58-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,3,6,0 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 843608-58:
(8*8)+(7*4)+(6*3)+(5*6)+(4*0)+(3*8)+(2*5)+(1*8)=182
182 % 10 = 2
So 843608-58-2 is a valid CAS Registry Number.
843608-58-2Relevant academic research and scientific papers
Palladium(II)-Catalyzed Enantioselective Synthesis of α-(Trifluoromethyl)arylmethylamines
Johnson, Thomas,Luo, Bo,Lautens, Mark
, p. 4923 - 4930 (2016/07/06)
We describe a method for the synthesis of α-(trifluoromethyl)arylmethylamines that consists of the palladium(II)-catalyzed addition of arylboroxines to imines derived from trifluoroacetaldehyde. Palladium acetate is used as a catalyst with electron-neutral or electron-rich arylboroxines, and it was found that addition of an ammonium or silver salt was crucial to promote the reaction of electron-poor boroxines. With (S)-t-Bu-PyOX as the chiral ligand, this method delivers a variety of α-trifluoromethylated amines in 57-91% yield and with greater than 92% ee in most cases.
