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Upstream product

• 100-46-9 benzylamine 
• 89525-53-1 1-bromo-2-benzylaminomethyl-4,5-dimethoxybenzene 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 1334295-99-6 ethyl N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-β-alaninate 

Relevant academic research and scientific papers

Palladium-mediated intramolecular Buchwald-Hartwig α-arylation of β-amino esters: Synthesis of functionalized tetrahydroisoquinolines

A concise and efficient three-step strategy for the synthesis of functionalized 1,2,3,4-tetrahydroisoquinolines based on an intramolecular Buchwald-Hartwig α-arylation of β-amino esters is described. The synthesis presented is operationally simple and is amenable for the synthesis of a number of analogues. Georg Thieme Verlag Stuttgart · New York.