89525-53-1

Upstream product

• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 100-46-9 benzylamine 

Downstream Products

• 89505-96-4 [(C₆H₂(OCH₃)2CH₂N(CH₂C₆H₅)HPd(P(C₆H₅)3)Br)] 
• 1294505-47-7 C₂₅H₂₄BrNO₂ 
• 1294505-46-6 C₂₉H₃₁BrClNO₂ 
• 1294505-58-0 C₂₉H₃₂ClNO₂ 
• 1334296-05-7 ethyl 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolidine-4-carboxylate 
• 1334295-99-6 ethyl N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-β-alaninate 
• 1395878-73-5 tert-butyl 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-4-carboxylate 
• 1417155-82-8 2-benzyl-6,7-dimethoxy-4-(9H-xanthen-9-ylidene)-1,2,3,4-tetrahydroisoquinoline 
• 1417155-71-5 N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-3-(2-phenoxyphenyl)-1-p-tolyl-prop-2-yn-1-amine 
• 1417155-78-2 2-benzyl-6,7-dimethoxy-3-p-tolyl-4-(9H-xanthen-9-ylidene)-1,2,3,4-tetrahydroisoquinoline 
• 1417155-72-6 N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-1-(4-methoxyphenyl)-3-(2-phenoxyphenyl)prop-2-yn-1-amine 
• 1417155-79-3 2-benzyl-6,7-dimethoxy-3-(4-methoxyphenyl)-4-(9H-xanthen-9-ylidene)-1,2,3,4-tetrahydroisoquinoline 
• 1417155-73-7 N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-1-(naphthalen-1-yl)-3-(2-phenoxyphenyl)prop-2-yn-1-amine 
• 1417155-80-6 2-benzyl-6,7-dimethoxy-3-(naphthalen-1-yl)-4-(9H-xanthen-9-ylidene)-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

A simple efficient sequential one-pot intermolecular aza-Michael addition and intramolecular Buchwald-Hartwig α-arylation of amines: Synthesis of functionalized tetrahydroisoquinolines

An efficient one-pot sequential intermolecular aza-Michael addition and Pd-catalyzed intramolecular Buchwald-Hartwig α-arylation of secondary amines have been investigated, for the synthesis of tetrahydroisoquinolines. This method is simple and furnished

Palladium-mediated intramolecular Buchwald-Hartwig α-arylation of β-amino esters: Synthesis of functionalized tetrahydroisoquinolines

A concise and efficient three-step strategy for the synthesis of functionalized 1,2,3,4-tetrahydroisoquinolines based on an intramolecular Buchwald-Hartwig α-arylation of β-amino esters is described. The synthesis presented is operationally simple and is amenable for the synthesis of a number of analogues. Georg Thieme Verlag Stuttgart · New York.

Synthesis of Medium Ring Nitrogen Heterocycles via a Tandem Copper-Catalyzed C-N Bond Formation-Ring-Expansion Process

A simple method for the preparation of medium ring heterocycles (7-, 8-, 9-, and 10-membered) has been developed. The process employs a Cu-catalyzed coupling of a β-lactam with an aryl bromide or iodide followed by intramolecular attack of a pendant amino group. In some instances, the intermediate β-lactam is observable but can be converted to the aza-heterocycle by catalysis. Acetic acid was found to be superior to transition metal complexes as a catalyst for this ring-expansion process.

PALLADIUM ASSISTED ORGANIC REACTIONS. VII. THE PREPARATION OF CYCLOPALLADATED PRIMARY AND SECONDARY BENZYLAMINES

A new method is described for the preparation of cyclopalladated benzylamines, involving the reaction of the ortho-bromobenzylamines with bis(dibenzylideneacetone)palladium(0).By using this method cyclopalladated complexes of simple primary and secondary benzylamines have been obtained for the first time.These complexes have been fully characterised as either the monomeric bromo(benzylamine-6-C,N)triphenylphosphinepalladium(II) derivatives or as the corresponding acetyl-acetonates. 1H and 13C NMR spectral data have been obtained and, in most cases, full assignments have been made.