1334308-69-8

Basic information

• Product Name: C₂₅H₃₉N₃O₂
• CAS NO: 1334308-69-8
• Molecular Weight: 413.604
• Mol File: 1334308-69-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₉N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₉N₃O₂(1334308-69-8)
• EPA Substance Registry System: C₂₅H₃₉N₃O₂(1334308-69-8)

Safety Data

• Hazardous Substances Data: 1334308-69-8(Hazardous Substances Data)

Upstream product

• 21043-40-3 1-cyclopentylpiperazine 
• 108-94-1 cyclohexanone 
• 42926-52-3 2-ethoxybenzoyl chloride 
• 1271072-95-7 C₁₆H₃₁N₃ 

Relevant articles and documents

Discovery of a novel series of selective HCN1 blockers

The discovery of a series of novel, potent, and selective blockers of the cyclic nucleotide-modulated channel HCN1 is disclosed. Here we report an SAR study around a series of selective blockers of the HCN1 channel. Utilization of a high-throughput VIPR assay led to the identification of a novel series of 2,2-disubstituted indane derivatives, which had moderate selectivity and potency at HCN1. Optimization of this hit led to the identification of the potent, 1,1-disubstituted cyclohexane HCN1 blocker, 2-ethoxy-N-((1-(4- isopropylpiperazin-1-yl)cyclohexyl)methyl)benzamide. The work leading to the discovery of this compound is described herein.