1334335-36-2

Upstream product

• 106-41-2 4-bromo-phenol 
• 64010-38-4 1-bromo-4-(3-chloropropoxy)benzene 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 415936-57-1 1-bromo-4-(3-piperidin-1-yl-propoxy)benzene 

Downstream Products

• 1334335-26-0 C₁₉H₂₉NO₂ 
• 1334335-38-4 C₁₉H₂₇NO₂ 

Relevant academic research and scientific papers

Novel and highly potent histamine H3 receptor ligands. Part 3: An alcohol function to improve the pharmacokinetic profile

Synthesis and biological evaluation of potent histamine H3 receptor antagonists incorporating a hydroxyl function are described. Compounds in this series exhibited nanomolar binding affinities for human receptor, illustrating a new possible component for the H3 pharmacophore. As demonstrated with compound BP1.4160 (cyclohexanol 19), the introduction of an alcohol function counter-intuitively allowed to reach high in vivo efficiency and favorable pharmacokinetic profile with reduced half-life.

Novel and highly potent histamine H3 receptor ligands. Part 1: Withdrawing of hERG activity

Pre-clinical investigation of some aryl-piperidinyl ether histamine H3 receptor antagonists revealed a strong hERG binding. To overcome this issue, we have developed a QSAR model specially dedicated to H3 receptor ligands. This model was designed to be di