415936-57-1

Basic information

• Product Name: 1-bromo-4-(3-piperidin-1-yl-propoxy)benzene
• Synonyms: 1-bromo-4-(3-piperidin-1-yl-propoxy)benzene
• CAS NO: 415936-57-1
• Molecular Weight: 298.223
• Mol File: 415936-57-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-bromo-4-(3-piperidin-1-yl-propoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-(3-piperidin-1-yl-propoxy)benzene(415936-57-1)
• EPA Substance Registry System: 1-bromo-4-(3-piperidin-1-yl-propoxy)benzene(415936-57-1)

Safety Data

• Hazardous Substances Data: 415936-57-1(Hazardous Substances Data)

Upstream product

• 1458-63-5 N-(3-chloropropyl)-piperidine 
• 106-41-2 4-bromo-phenol 
• 110-89-4 piperidine 
• 64010-38-4 1-bromo-4-(3-chloropropoxy)benzene 

Downstream Products

• 554430-30-7 5-(tert-butyl-dimethyl-silyloxy)-2-(7-(tert-butyl-dimethyl-silyloxy)-4-{1-hydroxy-1-[4-(3-piperidin-1-yl-propoxy)-phenyl]-ethyl}-2H-chromen-3-yl)-phenol 
• 1334335-36-2 C₁₉H₂₉NO₃ 
• 1334335-15-7 C₁₈H₂₃NOS 
• 1334335-26-0 C₁₉H₂₉NO₂ 
• 1334335-37-3 C₂₀H₂₉NO 
• 1334335-38-4 C₁₉H₂₇NO₂ 
• 1334335-22-6 C₁₉H₂₇NO 
• 1334335-24-8 C₂₀H₃₁NO 
• 1334335-30-6 C₂₀H₃₁NO₂ 
• 1334335-16-8 C₁₈H₂₃NO₂ 
• 1334335-27-1 C₂₁H₂₅NO₃ 
• 401895-68-9 1-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)piperidine 
• 1431139-68-2 C₁₈H₂₇NO₂ 
• 1431139-67-1 C₁₉H₃₁NO₂ 

Relevant articles and documents

Novel and highly potent histamine H3 receptor ligands. Part 3: An alcohol function to improve the pharmacokinetic profile

Synthesis and biological evaluation of potent histamine H3 receptor antagonists incorporating a hydroxyl function are described. Compounds in this series exhibited nanomolar binding affinities for human receptor, illustrating a new possible component for the H3 pharmacophore. As demonstrated with compound BP1.4160 (cyclohexanol 19), the introduction of an alcohol function counter-intuitively allowed to reach high in vivo efficiency and favorable pharmacokinetic profile with reduced half-life.

COMBINATION OF MODAFINIL AND AN ANTAGONIST OR INVERSE AGONIST OF THE H3 RECEPTOR

The invention relates to a combination of modafinil and at least one histamine H3 receptor antagonist or inverse agonist, which can be used in particular for the treatment of narcolepsy-cataplexy and more generally for disorders of sleep, wakefulness and vigilance.

Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands

The present patent application concerns compounds of formula (I), with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.