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CAS

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1334336-05-8

6-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1334336-05-8 Structure

  • Basic information

    1. Product Name: 6-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    2. Synonyms:
    3. CAS NO:1334336-05-8
    4. Molecular Formula:
    5. Molecular Weight: 406.508
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1334336-05-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine(1334336-05-8)
    11. EPA Substance Registry System: 6-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine(1334336-05-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1334336-05-8(Hazardous Substances Data)

1334336-05-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1334336-05-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,4,3,3 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1334336-05:
(9*1)+(8*3)+(7*3)+(6*4)+(5*3)+(4*3)+(3*6)+(2*0)+(1*5)=128
128 % 10 = 8
So 1334336-05-8 is a valid CAS Registry Number.

1334336-05-8Downstream Products

1334336-05-8Relevant articles and documents

Safety and Efficacy of New 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine Analogs as Potential Phosphodiesterase-4 Inhibitors in NIH-3T3 Mouse Fibroblastic Cells

Baeeri, Maryam,Foroumadi, Alireza,Motamedi, Maryam,Yahya-Meymandi, Azadeh,Firoozpour, Loghman,Ostad, Seyed N.,Shafiee, Abbas,Souzangarzadeh, Saeid,Abdollahi, Mohammad

, p. 438 - 444 (2011)

A novel series of potential phosphodiesterase-4 (PDE-4) inhibitors, 6-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, were developed. Different concentrations of the synthesized compounds were tested on cultured NIH-3T3 cells to determine their safety and efficacy in NIH-3T3 mouse fibroblastic cells in comparison with rolipram, a selective PDE-4 inhibitor. The viability of cells was determined by (3-(4,5-dimethylthiazol-2-yl)-2,5-di-phenyltetrazoliumbromide (MTT) assay. The PDE inhibition rate was measured indirectly by determination of concentrations of extracellular cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) using enzyme-linked immunoassay technique. The results showed that all tested compounds caused a marked increase in the concentration of cAMP, whereas the concentration of cGMP stayed approximately unchanged. The cytotoxic IC50 of all synthesized compounds was approximately twofold greater than their required concentration for inhibition of PDE-4 (in terms of elevation of cAMP), and thus, these structures could be used to develop potent and safe inhibitors of PDE-4 enzyme.

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