1334337-70-0Relevant articles and documents
A simple and efficient route to the FKBP-binding domain from rapamycin
Li, Wei,Bhat, Shridhar,Liu, Jun O.
, p. 5070 - 5072 (2011)
A simple and highly efficient route to the FKBP-binding domain (FKBD) from the natural product rapamycin has been developed, which entails a sequence of ozonolysis/Baeyer-Villiger/Wittig reactions. The newly synthesized FKBD may serve as a core to assembl
HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF
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Page/Page column 68, (2012/06/16)
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.