1334377-65-9Relevant academic research and scientific papers
New dinucleoside phosphonate derivatives as prodrugs of 3′-Azido-3′-deoxythymidine and β -L-2′,3′-Dideoxy- 3′-Thiacytidine: Synthesis and Anti-HIV Properties
Solyev, Pavel N.,Jasko, Maxim V.,Karpenko, Inna L.,Sharkin, Yury A.,Shipitsyn, Alexander V.,Kukhanova, Marina K.
, p. 64 - 79 (2014/04/17)
New phosphonate homodimers of 3′-azido-3′-deoxythymidine (AZT) and a phosphonate heterodimer of β-L-2′,3′-dideoxy-3′- thiacytidine (3TC) and AZT were synthesized. The compounds demonstrated moderate anti-HIV activity. Stability of the compounds in human blood serum was studied. A correlation between anti-HIV activity and stability was defined. 2014 Copyright Taylor and Francis Group, LLC.
