1334446-19-3

Upstream product

• 103-84-4 Acetanilid 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 125917-60-4 2-chloro-3-(hydroxymethyl)quinoline 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 7689-03-4 camptothecin 
• 1334446-35-3 (Z)-5-([4-(2-chloroquinolin-3-yl)methoxy]benzylidine)thiazolidine-2,4-dione 
• 1334446-27-3 4-((2-chloroquinolin-3-yl)methoxy)benzaldehyde 
• 1391868-19-1 ethyl 4-(4-((2-chloroquinolin-3-yl)methoxy)phenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Synthesis of New dihydropyrimidinones catalysed by dicationic ionic Liquid

A convenient multi step synthetic protocol for new dihydropyrimidinones bearing quinolynyl methoxy phenyl moiety has been developed from 2-chloro-3-formyl quinolines. The last step is one-pot Biginelli reaction of multicomponents, 4-((2-chloroquinolin-3-yl) methoxy) benzaldehydes, ethyl acetoacetate and urea mediated and catalysed by dicationic ionic liquid (3-methyl-1-[3-(methyl-1H-imidazolium-1-yl) propyl]- 1H-imidazolium dibromide (C3 [min]2 2 [Br-] )). Simple work-up procedures and moderate to good yields of the pyrimidinones and the intermediates are the merits of the route. Indian Academy of Sciences.

A novel and enantioselective total synthesis of (20 S)-camptothecin via a Sharpless asymmetric dihydroxylation strategy

A novel and efficient asymmetric total synthesis of (20S)-camptothecin has been accomplished in an overall yield of 12% starting from the commercially available 2-methoxynicotinic acid. The key step in the sequence is the Sharpless asymmetric dihydroxylation of a 4-(but-1-en-2-yl)pyridine derivative to establish the stereocenter of (20S)-camptothecin. Georg Thieme Verlag Stuttgart · New York.

Synthetic Route for New (Z)-5-[4-(2-Chloroquinolin-3-yl) Methoxy]benzylidinethiazolidine-2,4-diones

Synthetic route has been developed for the synthesis of new (Z)-5-[4-(2-chloroquinolin-3-yl) methoxy]benzylidinethiazolidine-2,4-diones (6a-h) starting from 2-chloro-3-hydroxymethyl quinolines (2a-h). The hydroxy methyl quinolines on tosylation yielded (3a-h). Condensation of the tosyl intermediates with 4-hydroxy benzaldehydes has been carried in DMF in presence of K2CO3 and obtained 4-quinolinyl methoxy benzaldehydes (4a-h). Conveniently Knoevenagel condensation of quinolinyl methoxy benzaldehydes (4a-h) and 2, 4-thiazolidinedione (5) has been carried in PEG-400 in presence of L-proline and obtained better yields of the titled compounds (6a-h).