1334446-35-3

Upstream product

• 2295-31-0 thiazoline-2,4-dione 
• 1334446-27-3 4-((2-chloroquinolin-3-yl)methoxy)benzaldehyde 
• 1334446-19-3 (2-chloroquinolin-3-yl)methyl 4-methylbenzenesulfonate 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 125917-60-4 2-chloro-3-(hydroxymethyl)quinoline 

Relevant academic research and scientific papers

Synthetic Route for New (Z)-5-[4-(2-Chloroquinolin-3-yl) Methoxy]benzylidinethiazolidine-2,4-diones

Synthetic route has been developed for the synthesis of new (Z)-5-[4-(2-chloroquinolin-3-yl) methoxy]benzylidinethiazolidine-2,4-diones (6a-h) starting from 2-chloro-3-hydroxymethyl quinolines (2a-h). The hydroxy methyl quinolines on tosylation yielded (3a-h). Condensation of the tosyl intermediates with 4-hydroxy benzaldehydes has been carried in DMF in presence of K2CO3 and obtained 4-quinolinyl methoxy benzaldehydes (4a-h). Conveniently Knoevenagel condensation of quinolinyl methoxy benzaldehydes (4a-h) and 2, 4-thiazolidinedione (5) has been carried in PEG-400 in presence of L-proline and obtained better yields of the titled compounds (6a-h).