1334474-13-3Relevant academic research and scientific papers
Fluorescent and antioxidant studies of effectively synthesized isochromenopyrrolone analogues
Reddy, Hariyapureddy Raveendranatha,Subba Reddy, Chitreddy V.,Subashini, Radhakrishnan,Roopan, Selvaraj Mohana
, p. 29999 - 30003 (2014)
An efficient strategy for the synthesis of 3-acetyl-2-methyl-1- phenylisochromeno [4,3-b] pyrrol-5(1H)-ones 4a-f have been developed using montmorillonite K10 as a catalyst. The reaction proceeded from acetyl acetone, substituted primary amines and ninhydrin via acidic media under solvent-free conditions. Compounds 4a-c exhibit green fluorescence under UV light, and their fluorescent properties in the liquid state were investigated. All the synthesized compounds were subjected for the evaluation of their free radical scavenging activity. Among all the tested compounds 4a and 4c exhibited good percentage inhibition in comparison with the standard, i.e. ascorbic acid. the Partner Organisations 2014.
Silica sulfuric acid: A reusable solid catalyst for one pot synthesis of densely substituted pyrrole-fused isocoumarins under solvent-free conditions
Pathak, Sudipta,Debnath, Kamalesh,Pramanik, Animesh
, p. 2344 - 2353 (2014/01/06)
A convenient and efficient methodology for the synthesis of densely substituted pyrrole-fused isocoumarins, which employs solidsupported silica sulfuric acid (SSA) as catalyst, has been developed. When the mixture of ninhydrin adducts of acetylacetone/ethyl acetoacetate and primary amines was heated on the solid surface of SSA under solvent-free conditions, the pyrrole-fused isocoumarins were formed in good yields. This synthetic method has several advantages such as the employment of solvent-free reaction conditions without the use of any toxic reagents and metal catalysts, the ease of product isolation, the use of a recyclable catalyst, the low cost, the easy availability of the starting materials, and the excellent yields of products.
Facile synthesis of substituted pyrrole-fused isocoumarins from ninhydrin
Pathak, Sudipta,Kundu, Ashis,Pramanik, Animesh
, p. 5180 - 5183 (2011/10/12)
A simple and efficient procedure has been developed for the synthesis of substituted pyrrole-fused isocoumarins from easily available ninhydrin. The cyclic hemiaminal dihydroxy-indenopyrroles, the adducts of ninhydrin with enamines of acetylacetone, give pyrrole-fused isocoumarins upon heating in acidic medium. The process constitutes an interesting acid-catalyzed rearrangement to eight-membered lactams followed by intramolecular cyclization involving the amino and keto groups.
