1334481-22-9

Upstream product

• 2315-86-8 3-bromo-4-hydroxybenzonitrile 
• 411235-57-9 cyclopropylboronic acid 

Downstream Products

• 1334481-23-0 4-cyano-2-cyclopropylphenyl trifluoromethanesulfonate 
• 1334481-27-4 Ethyl 3-(2-cyclopropyl-4-(5-(1-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1 H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)propanoate 
• 1334481-24-1 ethyl 3-(4-cyano-2-cyclopropylphenyl)acrylate 
• 1334481-25-2 ethyl 3-(2-cyclopropyl-4-(N'-hydroxycarbamimidoyl)phenyl)acrylate 
• 1334481-26-3 ethyl 3-(2-cyclopropyl-4-(N'-hydroxycarbamimidoyl)phenyl)propanoate 

Relevant academic research and scientific papers

Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity

The sphingosine-1-phosphate (S1P) signaling pathway is an attractive drug target due to its involvement in immune cell chemotaxis and vascular integrity. The formation of S1P is catalyzed by sphingosine kinase 1 or 2 (SphK1 or SphK2) from sphingosine (Sph

New oxadiazole derivatives

The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or N-oxide thereof: and its use in the treatment of diseases which are susceptible to improvement by sphingosine-1-phosphate (S1P1) receptor agonists.

NEW OXADIAZOLE DERIVATIVES

The present invention relates to an oxadiazole derivative of formula (I)1 or a pharmaceutically acceptable salt or N-oxide thereof: wherein, R1 represents a hydrogen atom, a C1-2 alkyl group or a C3-4 cycloalkyl-C1-2