1334483-05-4

Basic information

• Product Name: (S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate
• CAS NO: 1334483-05-4
• Molecular Weight: 362.469
• Mol File: 1334483-05-4.mol

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate(1334483-05-4)
• EPA Substance Registry System: (S)-tert-butyl 3-(4-benzoyl-2-(2-hydroxyethyl)piperazin-1-yl)propanoate(1334483-05-4)

Safety Data

• Hazardous Substances Data: 1334483-05-4(Hazardous Substances Data)

Upstream product

• 93-97-0 benzoic acid anhydride 
• 1663-39-4 tert-Butyl acrylate 
• 660862-47-5 (S)-2-(piperazin-2-yl)ethan-1-ol 
• 52661-95-7 (S)-ethyl 2-(3,6-dioxopiperazin-2-yl)acetate 

Downstream Products

• 1334482-99-3 C₂₀H₂₈N₂O₃ 
• 764714-59-2 ((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol 

Relevant articles and documents

Synthesis of a bicyclic piperazine from l-aspartic acid and application of a fluoride-promoted SNAr coupling

The process development is reported of a pivotal C-N bond formation involving ((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol (2) undergoing nucleophilic aromatic substitution with 3-chlorobenzo[d]isoxazole (3) to furnish ((7R,9aS)-2-(benzo[d]isoxazol-3-yl)octahydro-1H-pyrido[1,2-a] pyrazin-7-yl)methanol (4) as a key intermediate for a family of compounds (1). Essential to the success of the coupling is the use of fluoride in combination with a phase transfer catalyst. The development of an alternative route to bicyclic piperazine 2 that uses l-aspartic acid (20) as a starting material to avoid the need for a classical salt resolution is described.