1334499-91-0

Basic information

• Product Name: 1-(2,4-Difluorophenyl)pyrrolidine
• Synonyms: 1-(2,4-Difluorophenyl)pyrrolidine
• CAS NO: 1334499-91-0
• Molecular Formula: C₁₀H₁₁F₂N
• Molecular Weight: 183.1978464
• Mol File: 1334499-91-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2,4-Difluorophenyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-Difluorophenyl)pyrrolidine(1334499-91-0)
• EPA Substance Registry System: 1-(2,4-Difluorophenyl)pyrrolidine(1334499-91-0)

Safety Data

• Hazardous Substances Data: 1334499-91-0(Hazardous Substances Data)

Usage

General Description

1-(2,4-Difluorophenyl)pyrrolidine is a chemical compound with a 2,4-difluorophenyl group attached to a pyrrolidine ring. It is a synthetic compound that has potential applications in pharmaceutical research and drug development. The presence of the difluorophenyl group gives this compound unique chemical and pharmacological properties, which makes it useful for studying the structure-activity relationship of various drugs. Additionally, 1-(2,4-Difluorophenyl)pyrrolidine may also have potential use as a building block in organic synthesis for creating new compounds with specific properties or functionalities. Further research is needed to explore the full potential of this chemical in various applications.

Upstream product

• 109-99-9 tetrahydrofuran 
• 367-25-9 2,4-difluorophenylamine 
• 72624-70-5 2,4-difluorophenylethylamine 

Relevant articles and documents

Practical direct synthesis of: N -aryl-substituted azacycles from N -alkyl protected arylamines using TiCl4and DBU

A novel transformation of N-alkyl protected arylamines and cyclic ethers into N-aryl substituted azacycles is described. Alkyl groups have been used for the protection of amines in organic syntheses. In this synthesis, N-alkyl protected arylamines were reacted with cyclic ethers in the presence of TiCl4 and DBU, crucial reagents affording five- and six-membered azacycles. In particular, utilization of the novel TiCl4/DBU-mediated reaction allows various N-alkyl protected arylamines such as N-methyl-, N-ethyl-, N-isopropyl, and N-tert-butyl arylamines to be readily converted into N-aryl substituted azacycles in high yields. This practical approach using various N-alkyl arylamines leads to the efficient preparation of azacycles.

Metal-Free Synthesis of N-Aryl-Substituted Azacycles from Cyclic Ethers Using POCl3

A facile method for the synthesis of N-aryl-substituted azacycles from arylamines and cyclic ethers has been developed. In this study, arylamines were treated with cyclic ethers in the presence of POCl3 and DBU to provide five- A nd six-membered azacycles. Using this method, various azacycloalkanes, isoindolines, and tetrahydroisoquinolines were prepared in high yields. This synthetic method offers an efficient approach to the production of azacycles from cyclic ethers.

Boron trifluoride-mediated synthesis of N-aryl-substituted pyrrolidines from tetrahydrofuran and amines

[Figure not available: see fulltext.] Boron trifluoride-mediated transformation of tetrahydrofuran to corresponding N-aryl-substituted pyrrolidines is conducted under mild reaction conditions, providing a practical synthetic method with reasonable yields. Computational studies confirmed the reaction mechanism involving a fast Lewis acid-assisted ring-opening step, followed by the 7-membered intermediate formation and a ringclosing process as the rate-determining step.