1334512-07-0Relevant academic research and scientific papers
Chiral Diarylmethanes via Copper-Catalyzed Asymmetric Allylic Arylation with Organolithium Compounds
Guduguntla, Sureshbabu,Hornillos, Valentín,Tessier, Romain,Fa?anás-Mastral, Martín,Feringa, Ben L.
, p. 252 - 255 (2016/02/03)
A highly enantioselective copper/N-heterocyclic carbene catalyzed allylic arylation with organolithium compounds is presented. The use of commercial or readily prepared aryllithium reagents in the reaction with allyl bromides affords a variety of chiral diarylvinylmethanes, comprising a privileged structural motif in pharmaceuticals, in high yields with good to excellent regio- and enantioselectivities. The versatility of this new transformation is illustrated in the formal synthesis of the marketed drug tolterodine (Detrol).
Copper-catalyzed asymmetric allylic substitution of allyl phosphates with aryl- and alkenylboronates
Shintani, Ryo,Takatsu, Keishi,Takeda, Momotaro,Hayashi, Tamio
supporting information; experimental part, p. 8656 - 8659 (2011/11/06)
The asymmetric allylic substitution of allyl phosphates with aryl- and alkenylboronates catalyzed by a copper/N-heterocyclic carbene complex was developed and the substitution products were obtained with high enantioselectivity (see scheme). To account for the observed influence of the reaction parameters a possible catalytic cycle for this process was proposed. Copyright
