133454-46-3

Basic information

• Product Name: Desfluoro Iloperidone (IMpurity)
• Synonyms: Desfluoro Iloperidone (IMpurity);Iloperidone Desfluoro Impurity
• CAS NO: 133454-46-3
• Molecular Formula: C24H28N2O4
• Molecular Weight: 408.49012
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 133454-46-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Desfluoro Iloperidone (IMpurity)(CAS DataBase Reference)
• NIST Chemistry Reference: Desfluoro Iloperidone (IMpurity)(133454-46-3)
• EPA Substance Registry System: Desfluoro Iloperidone (IMpurity)(133454-46-3)

Safety Data

• Hazardous Substances Data: 133454-46-3(Hazardous Substances Data)

Usage

Uses

Desfluoro Iloperidone is the analog of Iloperidone (I267200), with potential application as an anti-psychotic due to the anti-psychotic profile of Iloperidone (I267200). Iloperidone (I267200) is noted for treatment of patients with psychological disorders, primarily schizophrenia in adults. An impurity in the synthesis of Iloperidone (I267200).

Upstream product

• 58113-30-7 4-(3-chloropropoxy)-3-methoxyacetophenone 
• 84163-22-4 3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 
• 584-08-7 potassium carbonate 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Relevant articles and documents

Improved and efficient process for the production of highly pure iloperidone: A psychotropic agent

The present work describes an improved and highly efficient process for the synthesis of iloperidone (1), an antipsychotic agent, which is free from potential impurities. The synthesis comprises N-alkylation of 1-(4-(3-chloropropoxy)-3-methoxyphenyl)ethanone (4) with 6-fluoro-3-piperidin-4- yl-1,2-benzisoxazole hydrochloride (5) in a mixture of water and heptane as solvent and sodium hydroxide as a base in the presence of tetrabutylammonium bromide as a phase transfer catalyst to yield iloperidone (1) with a yield of around 95% and a purity of 99.80% by HPLC. The present work also describes the optimization details performed to achieve the process attributes responsible for high yield and purity.

1-(arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-4-(heteroaryl) piperidines and related compounds useful as antipsychotics and analgesics

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics

Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.