1334540-50-9

Upstream product

• 1334540-38-3 S-(2-methyl-5-tert-butylphenyl)-4,6-O-benzylidene-3-O-tertbutyldimethylsilyl-1-thio-?-D-glucopyranoside 
• 98-88-4 benzoyl chloride 
• 7340-90-1 2-methyl-5-tert-butylthiophenol 
• 604-69-3 β-D-glucose pentaacetate 
• 1334540-35-0 (2-methyl-5-tert-butylphenyl) 4,6-O-benzylidene-1-thio-β-D-glucopyranoside 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 93-97-0 benzoic acid anhydride 
• 1334540-33-8 (2-methyl-5-tert-butylphenyl) 2,3,4,6-tetra-O-acetyl-1-S-β-D-thioglucopyranoside 
• 1421758-31-7 (2-methyl-5-tert-butylphenyl) 1-thio-β-D-glucopyranoside 

Downstream Products

• 1334540-20-3 S-(2-methyl-5-tert-butylphenyl) 2-O-benzoyl-4,6-O-benzylidene-3-O-fluorenylmethoxycarbonyl-1-thio-β-D-glucopyranoside 
• 1334540-22-5 2-O-benzoyl-4,6-O-benzylidene-3-O-fluorenylmethoxycarbonyl-D-glucopyranoside N-phenyltrifluoroacetimidate 
• 1421758-36-2 O,O-dibutyl-2-O-benzoyl-4,6-O-benzylidene-3-O-fluorenyl-methoxycarbonyl-α-D-gluco-pyranosidephosphate 
• 1334540-24-7 O,O-dibutyl-2-O-benzoyl-4,6-O-benzylidene-3-O-fluorenyl-methoxycarbonyl-β-D-gluco-pyranosidephosphate 
• 1444827-16-0 (2-methyl-5-tert-butylphenyl) 2-O-benzoyl-4,6-di-O-benzyl-1-thio-β-D-glucopyranoside 
• 1421767-98-7 2-methyl-5-tert-butylphenyl 2-O-benzoyl-4,6-di-O-benzyl-3-O-tert-butyldimethylsilyl-1-thio-β-D-glucopyranoside 
• 1421767-99-8 (2-methyl-5-tert-butylphenyl) 2-O-benzoyl-4,6-di-O-benzyl-3-O-tert-butyldimethylsilyl-1-thio-β-D-glucopyranoside 

Relevant academic research and scientific papers

Automated glycan assembly of branched β-(1,3)-glucans to identify antibody epitopes

β-(1,3)-Glucans exhibit immunomodulatory and anti-tumor effects. Since the isolation of pure β-(1,3)-glucan oligosaccharides from natural sources is complicated, especially when certain branching patterns are desired, chemical synthesis is frequently the

Oligosaccharides and oligosaccharides-protein conjugates derived from clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools

The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide α-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[α-L-Rhap-(1→3)]-α-D-Glcp-(1→2)-α-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools. A preferred method for synthesizing the pentasaccharide is shown below.

Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: Synthesis of the cell-surface polysaccharide PS-I repeating unit

Clostridium difficile strain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks.