133457-79-1

Basic information

• Product Name: Phosphinic acid, (diethoxymethyl)(phenylmethyl)-, ethyl ester
• CAS NO: 133457-79-1
• Molecular Formula: C14H23O4P
• Molecular Weight: 286.308
• Mol File: 133457-79-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phosphinic acid, (diethoxymethyl)(phenylmethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinic acid, (diethoxymethyl)(phenylmethyl)-, ethyl ester(133457-79-1)
• EPA Substance Registry System: Phosphinic acid, (diethoxymethyl)(phenylmethyl)-, ethyl ester(133457-79-1)

Safety Data

• Hazardous Substances Data: 133457-79-1(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 65600-74-0 ethyl diethoxymethylphosphinate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 20394-86-9 benzylphosphinic acid 
• 133457-80-4 diethoxymethyl(cyclohexylmethyl)phosphinic acid ethyl ester 

Relevant articles and documents

Rapid and efficient synthesis of unsymmetrical phosphinic acids r′t(o)ohr″

A new synthesis of unsymmetrical phosphinic acids R′P(O)OHR″ has been evaluated, The first P-C bond was formed by base-promoted H-phosphinate alkylation of a protected H-phosphinate, which is easier and safer to handle, A onepot methodology was developed for the second P-C bond formation reaction that: involves the sila-Arbuzov reaction. This methodology was then extended to the synthesis of a dialkylphosphinic acid with an amino functionality.

P-subsituted propane-phosphinic acid compounds

Compounds of the formula I STR1 wherein either R1 is halogen, R1 ' is halogen or hydrogen and R2 and R2 ' denote hydrogen or R1 and R1 ' represent hydrogen, R2 is an aliphatic or aromatic radical and R2 ' is hydroxy or R2 and R2 ' together represent oxo, and wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms or, if R1 and R1 ' denote hydrogen, R2 represents an aromatic radical and R2 ' is hydroxy, R represents methyl, and their salts are useful as nootropics, antidepressants and/or anxiolytics. The can be manufacture by replacing any group R5 by hydrogen and/or converting any group Z0 into amino in a compound of formula II STR2 in which R, R1, R1 ', R2 and R2 ' have their previous significances, Z represents a protected or latent amino group Z0 and R4 denotes hydrogen or a hyddroxy-protective group R5, and wherein amino as a constituent of R and/or hydroxy R2 ' or oxo R2 +R2 ' may be present in a temporarily protected form.

Substituted propane-phosphinic acid compounds

Compounds of the formula I STR1 wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms, and wherein one of the groups R1, R2 and R3 represents hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, another one of R1, R2 and R3 is hydrogen or, in the case of R1 and R2, is hydroxy, and the remaining one of R1, R2 and R3 is hydrogen, or wherein R denotes methyl, R1 denotes hydrogen or hydroxy, R2 denotes an aromatic radical and R3 represents hydrogen, and their salts have GABAB -antagonistic properties and can be used as GABAB -antagonists. They are obtained when in a compound of formula II STR2 in which R, R1, R2 and R3 have their previous significances, Z represents --NH2 and R4 denotes a hydroxy-protective group R5 or, when R1 and R3 denote hydrogen and R2 denotes hydrogen or alkyl, denotes an alkali metal or ammonium ion R6, or Z represents a protected or latent amino group Z0 and R4 denotes hydrogen or a hydroxy-protective group R5, any group R5 or R6 is replaced by hydrogen, and/or any group Z0 is converted into --NH2.