133457-85-9Relevant academic research and scientific papers
P-subsituted propane-phosphinic acid compounds
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, (2008/06/13)
Compounds of the formula I STR1 wherein either R1 is halogen, R1 ' is halogen or hydrogen and R2 and R2 ' denote hydrogen or R1 and R1 ' represent hydrogen, R2 is an aliphatic or aromatic radical and R2 ' is hydroxy or R2 and R2 ' together represent oxo, and wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms or, if R1 and R1 ' denote hydrogen, R2 represents an aromatic radical and R2 ' is hydroxy, R represents methyl, and their salts are useful as nootropics, antidepressants and/or anxiolytics. The can be manufacture by replacing any group R5 by hydrogen and/or converting any group Z0 into amino in a compound of formula II STR2 in which R, R1, R1 ', R2 and R2 ' have their previous significances, Z represents a protected or latent amino group Z0 and R4 denotes hydrogen or a hyddroxy-protective group R5, and wherein amino as a constituent of R and/or hydroxy R2 ' or oxo R2 +R2 ' may be present in a temporarily protected form.
