131971-65-8Relevant academic research and scientific papers
Enantioselective Friedel-Crafts reaction of electron-rich alkenes catalyzed by chiral Bronsted acid
Terada, Masahiro,Sorimachi, Keiichi
, p. 292 - 293 (2008/04/18)
We present the first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Bronsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the
P-subsituted propane-phosphinic acid compounds
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, (2008/06/13)
Compounds of the formula I STR1 wherein either R1 is halogen, R1 ' is halogen or hydrogen and R2 and R2 ' denote hydrogen or R1 and R1 ' represent hydrogen, R2 is an aliphatic or aromatic radical and R2 ' is hydroxy or R2 and R2 ' together represent oxo, and wherein R denotes an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic or araliphatic radical having 2 or more carbon atoms or, if R1 and R1 ' denote hydrogen, R2 represents an aromatic radical and R2 ' is hydroxy, R represents methyl, and their salts are useful as nootropics, antidepressants and/or anxiolytics. The can be manufacture by replacing any group R5 by hydrogen and/or converting any group Z0 into amino in a compound of formula II STR2 in which R, R1, R1 ', R2 and R2 ' have their previous significances, Z represents a protected or latent amino group Z0 and R4 denotes hydrogen or a hyddroxy-protective group R5, and wherein amino as a constituent of R and/or hydroxy R2 ' or oxo R2 +R2 ' may be present in a temporarily protected form.
A New Method for the Synthesis of N-t-Butoxycarbonyl protected α-Alkoxy Amines from Allylamines under Neutral Conditions
Nemoto, Hisao,Jimenez, Hermogenes N.,Yamamoto, Yoshinori
, p. 1304 - 1306 (2007/10/02)
Treatment of the Boc protected allylamines (4) with rhodium catalysts in the presence of alcohols produces N-Boc substituted α-alkoxy amines (5) in high yields, which can be used as a synthetic equivalents of activated imines having an easily deprotectable Boc group.
