1334592-36-7

Basic information

• Product Name: 2-(3-(benzo[d][1,3]dioxol-5-yl)-1,4,2-dioxazol-5-yl)pyridine
• Synonyms: 2-(3-(benzo[d][1,3]dioxol-5-yl)-1,4,2-dioxazol-5-yl)pyridine
• CAS NO: 1334592-36-7
• Molecular Weight: 270.244
• Mol File: 1334592-36-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-(benzo[d][1,3]dioxol-5-yl)-1,4,2-dioxazol-5-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(benzo[d][1,3]dioxol-5-yl)-1,4,2-dioxazol-5-yl)pyridine(1334592-36-7)
• EPA Substance Registry System: 2-(3-(benzo[d][1,3]dioxol-5-yl)-1,4,2-dioxazol-5-yl)pyridine(1334592-36-7)

Safety Data

• Hazardous Substances Data: 1334592-36-7(Hazardous Substances Data)

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 2089-36-3 (E)-3,4-methylenedioxybenzaldehyde oxime 

Relevant articles and documents

Novel terpene based 1,4,2-dioxazoles: Synthesis, characterization, molecular properties and screening against Entamoeba histolytica

In present investigation a series of 20 dioxazole analogues (1-20) were synthesized, characterized and subjected to molecular properties prediction, anti-amoebic screening and cytotoxicity evaluation. Out of the twenty compounds viz. 3,5-substituted-1,4,2-dioxazoles, six compounds have shown IC50 values in the range (1.00-1.10 μM) lower than the standard drug metronidazole (IC50 = 1.45 μM). The toxicological studies of the active compounds on H9c2 rat cardiac myoblasts showed that all compounds were nontoxic. The pKa, and log P values have also been predicted. Compound 8 showed the most promising results based on anti-amoebic evaluation, cytotoxicity studies and physico-chemical properties prediction.