1334682-53-9Relevant academic research and scientific papers
A facile pathway to enantiomerically enriched 3-hydroxy-2-oxindoles: Asymmetric intramolecular arylation of α-keto amides catalyzed by a palladium-DifluorPhos complex
Yin, Liang,Kanai, Motomu,Shibasaki, Masakatsu
, p. 7620 - 7623 (2011)
Less metal wastes: The first catalytic, enantioselective intramolecular aryl-transfer reaction of aryl triflates to ketones has been developed (see scheme; R1=R2=aromatic and aliphatic). This method features overall practicality, inc
Cobalt-Catalyzed Enantioselective Vinylation of Activated Ketones and Imines
Huang, Yuan,Huang, Rui-Zhi,Zhao, Yu
supporting information, p. 6571 - 6576 (2016/06/09)
We present here an unprecedented cobalt-catalyzed enantioselective vinylation of α-ketoesters, isatins, and imines to deliver a range of synthetically useful allylic alcohols and amines in high enantiopurity. This method employs commercially available and easy to handle catalysts and reagents and exhibits a high degree of practicality. The efficiency, selectivity, and operational simplicity of this catalytic system coupled with the substrate generality render this method a valuable tool in organic synthesis.
