1334686-06-4

Upstream product

• 1334686-10-0 C₂₈H₃₇N₃O₈S₂ 
• 1334686-03-1 N-[6-(2-tert-Butoxyethoxy)-2-hydroxy-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-4-tert-butylbenzenesulfonamide 

Downstream Products

• 1334686-05-3 trifluoromethanesulfonic acid 4-(2-tert-butoxyethoxy)-6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)pyrimidin-2-yl ester 
• 1334686-07-5 trifluoromethanesulfonic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-2-trifluoromethanesulfonyloxy-pyrimidin-4-yloxy]-ethyl ester 
• 147536-97-8 bosentan 
• 1334686-08-6 trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF BOSENTAN

The present invention provides a novel process for obtaining Bosentan, with few synthesis steps, by coupling the intermediate pyrimidine compound of formula I with the sulfonamide compound of formula II. The use of said efficient process prevents the use of hazardous chemicals and thus it is of considerable interest for obtaining Bosentan in a large industrial scale. The invention also refers to the novel intermediates of formula II and to a process for its production.

Process for the preparation of bosentan

The present invention provides a novel process for obtaining Bosentan, with few synthesis steps, by coupling the intermediate pyrimidine compound of formula I with the sulfonamide compound of formula II. The use of said efficient process prevents the use of hazardous chemicals and thus it is of considerable interest for obtaining Bosentan in a large industrial scale. The invention also refers to the novel intermediates of formula II and to a process for its production.