1334686-08-6

Basic information

• Product Name: trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester
• Synonyms: trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester
• CAS NO: 1334686-08-6
• Molecular Weight: 683.686
• Mol File: 1334686-08-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester(1334686-08-6)
• EPA Substance Registry System: trifluoromethanesulfonic acid 2-[6-(4-tert-butylbenzenesulfonylamino)-5-(2-methoxyphenoxy)-[2,2']bipyrimidinyl-4-yloxy]ethyl ester(1334686-08-6)

Safety Data

• Hazardous Substances Data: 1334686-08-6(Hazardous Substances Data)

Upstream product

• 1334686-10-0 C₂₈H₃₇N₃O₈S₂ 
• 1334686-06-4 4-tert-Butyl-N-[2-hydroxy-6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide 
• 1334686-03-1 N-[6-(2-tert-Butoxyethoxy)-2-hydroxy-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-4-tert-butylbenzenesulfonamide 
• 1334686-07-5 trifluoromethanesulfonic acid 2-[6-(4-tert-butyl-benzenesulfonylamino)-5-(2-methoxy-phenoxy)-2-trifluoromethanesulfonyloxy-pyrimidin-4-yloxy]-ethyl ester 
• 153435-63-3 2-(tributylstannyl)pyrimidine 

Downstream Products

• 147536-97-8 bosentan 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF BOSENTAN

The present invention provides a novel process for obtaining Bosentan, with few synthesis steps, by coupling the intermediate pyrimidine compound of formula I with the sulfonamide compound of formula II. The use of said efficient process prevents the use of hazardous chemicals and thus it is of considerable interest for obtaining Bosentan in a large industrial scale. The invention also refers to the novel intermediates of formula II and to a process for its production.