1334723-70-4Relevant academic research and scientific papers
Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline
Wu, Jing,Wang, Dadian,Chen, Xiang,Gui, Qingwen,Li, Hua,Tan, Ze,Huang, Genping,Wang, Guangwei
, p. 7509 - 7512 (2017)
A highly efficient synthesis of 4-benzylpyridines was developed via Pd-catalyzed C(sp3)-H arylation between 4-picoline and aryl halides. It was found that the best yields were achieved with a simple Pd(PPh3)4 catalyst and Cs2CO3 as the base. Compared with the known methods, our reaction does not require the use of a strong organometallic reagent as the base.
Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen
Sterckx, Hans,De Houwer, Johan,Mensch, Carl,Herrebout, Wouter,Tehrani, Kourosch Abbaspour,Maes, Bert U.W.
supporting information, p. 144 - 153 (2016/04/05)
The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoichiometric oxidant. Application of the protocol in API synthesis is exemplified by the alternative synthesis of a precursor to the antimalarial drug Mefloquine. The oxidation method can also be used to prepare metabolites of APIs which is illustrated for the natural product papaverine. ICP-MS analysis of the purified reaction products revealed that the base metal impurity was well below the regulatory limit.
Lewis acid promoted benzylic cross-couplings of pyridines with aryl bromides
Duez, Stephanie,Steib, Andreas K.,Manolikakes, Sophia M.,Knochel, Paul
supporting information; experimental part, p. 7686 - 7690 (2011/10/17)
Either ZnCl2, Sc(OTf)3, or BF3OEt 2 can promote the palladium-catalyzed arylation of methylpyridines and related heterocycles (see example). The complexation of the Lewis acid to the nitrogen atom in the heteroc
