1334848-95-1Relevant academic research and scientific papers
Synthesis of Activated Cyclopropanes by MHIRC Strategy: A Facile and Efficient Approach to Spirocyclopropanes Using N-Halosulfon-amides
Ghorbani-Vaghei, Ramin,Maghbooli, Yaser
, p. 3803 - 3811 (2016)
In this study, a one-pot, three-component reaction of two molecules of indane-1,3-dione with aromatic aldehydes for the synthesis of spirocyclopropylindanediones using poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) (PBBS), N,N,N',N'-tetrabromobenzene-1,3-
Facile synthesis of spirosubstituted cyclopropanes through reaction of electron-deficient olefins and 1,3-indandione
Huang, Jiamin,Liu, Wenli,Wang, Changqing,Yang, Liu,Cao, Xiaohua
, (2020)
An efficient and facile approach for the synthesis of spirosubstituted cyclopropane derivatives has been described. The reaction of 1,3-indandione with arylidenemalononitrile in the presence of molecular iodine and dimethylaminopyridine occurred to give c
Synthesis of activated cyclopropanes by an MIRC strategy: An enantioselective organocatalytic approach to spirocyclopropanes
Russo, Alessio,Meninno, Sara,Tedesco, Consiglia,Lattanzi, Alessandra
scheme or table, p. 5096 - 5103 (2011/10/12)
An efficient cyclopropanation, by a Michael-initiated ring-closing (MIRC) reaction of 2-arylidene-1,3-indandiones and 2-arylidene malononitriles, has been developed by using different α-monohalogenated methylene active compounds with triethylamine. The first enantioselective cyclopropanation to spirocyclopropanes derived by the reaction of 2-arylidene-1,3-indandiones and dimethyl bromomalonate with a commercially available α,α-L- diarylprolinol as the organocatalyst and K2CO3 as the additive has been accomplished. The spirocyclopropanes were isolated in high yield and up to 85% ee. Notably, the asymmetric one-pot sequential approach to spirocyclopropanes proved to be a feasible process. A simple triethylamine-promoted domino cyclopropanation of 2-arylidene-1,3-indandiones and 2-arylidenemalononitriles with α-monohalogenated methylene-active compounds has been efficiently developed. Spirocyclopropanes derived from 2-arylidene-1,3-indandiones were synthesized with up to 85% ee by using dimethyl bromomalonate and α,α-L-diarylprolinol/K2CO3 system. Copyright
