1335000-74-2

Upstream product

• 4640-66-8 p-chlorobenzoylacetonitrile 
• 139260-20-1 5-amino-3-(4-chlorophenyl)thiophene-2,4-dicarbonitrile 

Downstream Products

• 1335000-81-1 2-methyl-5-(4-chlorophenyl)-3,4-dihydro-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1335000-80-0 5-(4-chlorophenyl)-3,4-dihydro-2-(chloromethyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide 
• 1374790-71-2 5'-(4-chlorophenyl)-3',4'-dihydro-4'-oxo-1'H-spiro[cyclohexane-1,2'-thieno[2,3-d]pyrimidine]-6'-carboxamide 
• 1374790-67-6 2,5-di(4-chlorophenyl)-3,4-dihydro-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1374790-74-5 2,5-di-(4-chlorophenyl)-1,2,3,4-tetrahydro-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1374790-69-8 5-(4-chlorophenyl)-3,4-dihydro-2-(4-nitrophenyl)-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1374790-76-7 5-(4-chlorophenyl)-1,2,3,4-tetrahydro-2-(4-nitrophenyl)-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1374790-72-3 5-(4-chlorophenyl)-3,4-dihydro-2-phenyl-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1374790-70-1 5'-(4-chlorophenyl)-3',4'-dihydro-4'-oxo-1'H-spiro[cyclopentane-1,2'-thieno[2,3-d]pyrimidine]-6'-carboxamide 
• 1374790-68-7 5-(4-chlorophenyl)-3,4-dihydro-2-(2,4-dimethoxyphenyl)-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1374790-75-6 5-(4-chlorophenyl)-1,2,3,4-tetrahydro-2-(2,4-dimethoxyphenyl)-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1374790-73-4 5-(4-chlorophenyl)-3,4-dihydro-2-(3-chloropropyl)-4-oxothieno-[2,3-d]pyrimidine-6-carboxamide 
• 1374790-60-9 5-(4-chlorophenyl)-3,4-dihydro-4-oxothieno[2,3-d]pyrimidine-6-carboxamide 
• 1446090-65-8 4-(m-tolylamino)-5-(4-chlorophenyl)thieno[2,3-d]pyrimidine-6-carbonitrile 

Relevant academic research and scientific papers

Synthetic tactics of new class of 4-aminothieno[2,3-d]pyrimidine-6- carbonitrile derivatives acting as antimicrobial agents

Thermal selective reactions were studied on oxothieno[2,3-d]pyrimidine-6- carboxamide 3 with POCl3 and PCl5. At 25-50 C, the C 7-amide rearranges to nitrile furnished compound 4 in 85-90% yield, while at 80-110 C furnished

Synthesis of new thieno[2,3-d]pyrimidines, thieno[3,2-e]pyridines, and thieno[2,3-d][1,3]oxazines

o-Aminothiophene dicarbonitrile 1 on neat reaction with cyclic ketones in anhydrous ZnCl2 yielded mixture of fused aminopyridine 3 and iminospirooxazine 4 derivatives. Similarly, pyrimidine derivatives 5 and 8 were obtained by the reaction of this intermediate 1 with formic acid and DMF-DMA followed by hydrazine hydrate, respectively. The reaction of o-amino-thiophene dicarboxamide 2 at ambient temperature with cyclic ketones yielded spiropyrimidine 10 as a sole product in quantitative yield. The regioselective anellated pyrimidine 9, 11, and dihydropyrimidine 12 derivatives were also obtained by the reaction with aromatic aldehydes in presence of piperidine and iodine respectively. Copyright

Aminothiophenedicarboxamides and dicyanothiopheneacetamides as effective synthetic molluscicides against Indoplanorbis exustus snail

New thiophenedicarboxamide 2a-c and dicyanothiopheneacetamide 3a-c derivatives were synthesized and their bioactivity against Indoplanorbis exustus snails was evaluated. The I. exustus snail is a serious host of parasite of genus Schistosoma which infects cattle. Thus reduces livestock productivity and also acts as a source of cercarial dermatitis in human beings. The results obtained show a significant (P 50 = 0.6043 ppm for compound 2a and LC50 = 0.6511 ppm for compound 3a.