1335013-78-9

Upstream product

• 1335014-12-4 5-(4-methoxybenzyloxy)-1-phenylpent-1-yn-3-ol 
• 1335014-19-1 5-(4-methoxybenzyloxy)-1-phenylpent-1-yn-3-one 
• 2746-25-0 p-Methoxybenzyl bromide 
• 128461-65-4 3-(p-methoxybenzyloxy)propanal 
• 135362-69-5 3-(4-methoxybenzyl)oxypropan-1-ol 
• 119649-27-3 4-((4-methoxybenzyl)oxy)butanal 
• 119649-45-5 4-(p-methoxybenzyloxy)butan-1-ol 
• 591-50-4 iodobenzene 
• 444809-61-4 (3R)-5-[(4-methoxyphenyl)methoxy]pent-1-yn-3-ol 

Downstream Products

• 917251-13-9 (R,2Z,6E)-5-hydroxy-7-phenylhepta-2,6-dienoate 
• 1260145-38-7 (1E,3R,5S)-1-phenylocta-1,7-diene-3,5-diol 
• 1260145-21-8 (4S,6R)-4-allyl-2,2-dimethyl-6-[(E)-2-phenylvinyl]-1,3-dioxane 
• 1335014-32-8 (R,E)-5-(4-methoxybenzyloxy)-1-phenylpent-1-en-3-yl acetate 
• 1335014-38-4 (R,E)-5-hydroxy-1-phenylpent-1-en-3-yl acetate 
• 1335014-92-0 C₁₃H₁₄O₃ 
• 1335013-63-2 (3R,5S,E)-5-hydroxy-1-phenylocta-1,7-dien-3-yl acetate 
• 188054-12-8 (1E,3R,5S,7E)-5-hydroxy-8-((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)-1-phenylocta-1,7-dien-3-yl acetate 
• 1335014-61-3 methyl (5R,2Z,6E)-5-acetoxy-7-phenylhepta-2,6-dienoate 
• 1335014-28-2 (R,E)-5-(4-methoxybenzyloxy)-1-phenylpent-1-en-3-ol 
• 22639-28-7 (R)-goniothalamin 
• 1370368-71-0 (3R,5S)-1-phenyloct-7-en-1-yne-3,5-diol 

Relevant academic research and scientific papers

Stereoselective synthesis of the non-lactonic portion of (Z)-cryptofolione and approaches towards its conversion to (Z)-cryptofolione

The stereoselective synthesis of the non-lactonic part of the natural G2 checkpoint inhibitor, (Z)-cryptofolione, has been accomplished. Butane-1,4-diol was used as the starting material, and the stereogenic centers were generated through L-proline-catalyzed α-aminoxylation and Maruoka asymmetric allylation. We attempted to convert this non-lactonic moiety to (Z)-cryptofolione via olefin cross-metathesis reaction, but by this approach another naturally occurring lactonic compound, goniothalamin, was obtained.

Stereoselective total synthesis of (+)-cryptofolione and (+)-goniothalamin

The stereoselective total synthesis of two naturally occurring α-pyrone derivatives (+)-cryptofolione and (+)-goniothalamin has been accomplished via a common intermediate. The synthetic sequence involves the asymmetric reduction of a propargyl ketone and olefin cross-metathesis as the key reactions.