444809-61-4

Upstream product

• 444809-59-0 (2S,3R)-2-Chloromethyl-3-[2-(4-methoxy-benzyloxy)-ethyl]-oxirane 
• 119649-27-3 4-((4-methoxybenzyl)oxy)butanal 
• 119649-45-5 4-(p-methoxybenzyloxy)butan-1-ol 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 736140-63-9 5-(4-methoxy)benzyloxy-2R,3S-epoxy-1-pentanol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 242808-65-7 ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol 
• 218434-90-3 1-but-3-ynyloxymethyl-4-methoxy-benzene 
• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 
• 146916-76-9 5-(4-methoxyphenyl)methoxy-2-pentyn-1-ol 

Downstream Products

• 411241-99-1 (R)-tert-butyl(hex-5-en-1-yn-3-yloxy)diphenylsilane 
• 411242-11-0 3(R)-(tert-butyldiphenylsilanyloxy)pent-4-ynal 
• 1370368-71-0 (3R,5S)-1-phenyloct-7-en-1-yne-3,5-diol 
• 1335013-78-9 (3R)-5-[(4-methoxyphenyl)methoxy]-1-phenylpent-1-yn-3-ol 
• 855855-51-5 Benzoic acid (1S,3S,7R)-7-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-9-(4-methoxy-benzyloxy)-1-phenethyl-non-5-ynyl ester 
• 855855-59-3 (E)-(3S,5S,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-1-phenyl-undec-7-ene-3,5-diol 
• 855855-61-7 tert-Butyl-{(E)-(R)-4-((4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl)-1-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyloxy}-dimethyl-silane 
• 855855-63-9 (2Z,6E)-(R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-((4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl)-octa-2,6-dienoic acid ethyl ester 
• 855855-62-8 (E)-(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-((4S,6S)-2,2-dimethyl-6-phenethyl-[1,3]dioxan-4-yl)-hex-4-en-1-ol 
• 954134-26-0 C₂₇H₄₄O₇Si 

Relevant academic research and scientific papers

Stereoselective synthesis of the non-lactonic portion of (Z)-cryptofolione and approaches towards its conversion to (Z)-cryptofolione

The stereoselective synthesis of the non-lactonic part of the natural G2 checkpoint inhibitor, (Z)-cryptofolione, has been accomplished. Butane-1,4-diol was used as the starting material, and the stereogenic centers were generated through L-proline-catalyzed α-aminoxylation and Maruoka asymmetric allylation. We attempted to convert this non-lactonic moiety to (Z)-cryptofolione via olefin cross-metathesis reaction, but by this approach another naturally occurring lactonic compound, goniothalamin, was obtained.

A convergent approach for the total synthesis of (-)-synrotolide diacetate

A simple carbohydrate based convergent approach towards the total synthesis of (-)-synrotolide diacetate is described employing a Sharpless asymmetric epoxidation, a Grignard assisted lactol opening with a terminal alkyne and a Wittig reaction using the H

A carbohydrate-based approach for the total synthesis of strictifolione

A chiral pool approach starting with D-glucose, using the Yamaguchi protocol and a Z-selective HWE reaction followed by lactonization, has been applied to execute the total synthesis of strictifolione.

A study toward a total synthesis of fostriecin

In order to synthesize the major C(3)-C(12) part of fostriecin, asymmetric dihydroxylation of several dienes 5a-f, prepared by cross-coupling reactions of several types, was studied, thus providing high dependency on the hydroxyl groups at C(5) and C(11). The best regioselectivity was obtained with 5d to produce diol 23, which was later transformed into the advanced intermediate 26.