1335019-76-5Relevant academic research and scientific papers
A catalyst- and solvent-free multicomponent synthesis and docking study of some new antiproliferative: N 5-allyl-quinolylpyrido[2,3- b] [1,4]benzodiazepinone precursors
Barad, Hitesh A.,Sutariya, Tushar R.,Brahmbhatt, Gaurangkumar C.,Parmar, Narsidas J.,Lagunes, Irene,Padrón, José M.,Murumkar, Prashant,Sharma, Mayank Kumar,Yadav, Mange Ram
, p. 4931 - 4939 (2016)
A multicomponent reaction has been developed by incorporating quinoline-3-carbaldehyde, 1,3-cyclohexanedione and 2,3-diaminopyridine into some new quinolylpyrido[2,3-b][1,4]benzodiazepinone assemblies under catalyst- and solvent-free conditions at 120 °C. Further reaction of the resulting intermediates with allyl bromide led to the formation of the corresponding N5-allylated products, in situ, with higher yields in the same pot. Many candidates of this new class revealed noticeable activities against the representative human solid tumour cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast) and WiDr (colon). The most active compounds resemble the standard drug etoposide in antiproliferative activity against HeLa, T-47D and WiDr cell lines. Docking studies in the active site of MDM2 led us to consider this protein a plausible target for the antiproliferative effects of the compounds.
Schiff's base derivatives bearing nitroimidazole and quinoline nuclei: New class of anticancer agents and potential EGFR tyrosine kinase inhibitors
Makawana, Jigar A.,Sangani, Chetan B.,Lin, Lin,Zhu, Hai-Liang
, p. 1734 - 1736 (2014/04/17)
New Schiff's base derivatives 5a-j have been synthesized by reaction between 2-phenoxyquinoline-3-carbaldehydes 3a-j and 2-(2-methyl-5-nitro-1H- imidazol-1-yl)acetohydrazide 4 in presence of nickel(II) nitrate as a catalyst in ethanol under reflux in good
Microwave-assisted synthesis of novel 4H-chromene derivatives bearing 2-aryloxyquinoline and their antimicrobial activity assessment
Sangani, Chetan B.,Shah, Nimesh M.,Patel, Manish P.,Patel, Ranjan G.
, p. 3831 - 3842 (2013/07/26)
A new series of 4H-chromene derivatives 6a-x bearing 2-aryloxyquinoline nucleus have been synthesized under microwave irradiation by reaction of 2-aryloxyquinoline-3-carbaldehyde 3a-l, malononitrile 4, and compounds (Cyclohexanedione, Dimidone) 5a-b in th
Synthesis and identification of β-aryloxyquinolines and their pyrano[3,2-c]chromene derivatives as a new class of antimicrobial and antituberculosis agents
Mungra, Divyesh C.,Patel, Manish P.,Rajani, Dhanji P.,Patel, Ranjan G.
experimental part, p. 4192 - 4200 (2011/11/29)
A new class of β-aryloxyquinolines 3a-i and their pyrano[3,2-c] chromene derivatives 6a-r incorporating a validated molecular target has been synthesized via a nucleophilic displacement and a one-pot multicomponent reaction respectively. In vitro antimicr
