1335024-24-2Relevant articles and documents
Synthesis, Characterization, Thermochromism, and Photochromism of Aromatic Aldehyde Hydrazone Derivatives
Zhu, ShaoPing,Chen, Yuan,Sun, Jun,Yang, YuTing,Yue, ChuanJun
, (2016)
The Schiff bases N-(5-phenylthiazole-2-yl)-2-hydroxylnaphthaldehydehydrazone (1), N-(4′-chloro-5-phenylthiazole-2-yl)-2-hydroxylnaphthaldehydehydrazone (2), and N-(4′-nitro-5-phenylthiazole-2-yl)-2-hydroxylnaphthaldehydehydrazone (3) were synthesized. The
In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles
Hernández, Wilfredo,Vaisberg, Abraham. J.,Tobar, Mabel,álvarez, Melisa,Manzur, Jorge,Echevarría, Yuri,Spodine, Evgenia
, p. 1853 - 1860 (2016)
This work reports the synthesis and characterization of palladium(ii) complexes Pd(L1)2 (1), Pd(L2)2 (2), Pd(L3)2 (3) and Pd(L4)2 (4), where L1H: 1-naphthal
Syntheses, urease inhibition activities, and fluorescent properties of transition metal complexes
Qiu, Xiaoyang,Wang, Jing,Shi, Dahua,Li, Suzhi,Zhang, Fuli,Zhang, Fuqiang,Cao, Guangxiu,Zhai, Bin
, p. 1616 - 1625 (2013)
Four transition metal complexes with Schiff base and 1,10-phenanthroline, [Cu(L)(phen)]2·C2H5OH (1), [Zn(L)(phen)]2·C2H5OH (2), [Ni(L)(phen)]2·C2H5OH (3), and [Co(L)(phen)]2·C2H5OH (4) (H 2L = 1-((2-hydroxynaphthalen-1-yl)methylene)thiosemicarbazide; phen = 1,10-phenanthroline) were synthesized and characterized by physico-chemical methods The crystal structure of 1 was determined by X-ray single-crystal diffraction analysis 1 crystallizes in the orthorhombic space group Pbca with a = 15.008(9), b = 16.100(10), c = 37.54(2) A, V = 9070(10) A3, Z = 8, GOOF = 1.002, R1 = 0.0626, and wR 2 = 0.0912 The fluorescence and urease inhibitory activities of the compounds were tested The enzymatic activity study indicated that 3 possessed potent inhibition against jack bean urease, with IC50 = 1.2 ± 0.1 μM, and about 35 times more than 42.1 ± 0.4 acetohydroxamic acid as positive reference This suggests that inhibitory efficiency of these complexes can be strongly influenced by different transition metal ions
Mixed-ligand thiosemicarbazone complexes of nickel: Synthesis, structure and catalytic activity
Datta, Sayanti,Seth, Dipravath Kumar,Butcher, Ray J.,Bhattacharya, Samaresh
, p. 120 - 128 (2011)
Reaction of thiosemicarbazones of salicylaldehyde, 2-hydroxyacetophenone and 2-hydroxynaphthaldehyde with Ni(ClO4)2·6H 2O, using 2,2′-bipyridine as coligand, afforded three dinuclear complexes (1a, 1b and 1c). Similar reac
Potentiometric Studies on the Complexation Equilibria Between Some Trivalent Lanthanide Metal Ions and Biologically Active 2-Hydroxy-1-Naphthaldehyde Thiosemicarbazone (HNATS)
Sharma, Sahadev R. K.,Sindhwani, S. K.
, p. 883 - 890 (1992)
The chelation behaviour of some trivalent lanthanide and yttrium metal ion with biologically active 2-hydroxy-1-naphthaldehyde thiosemicarbazone (HNATS) has been investigated by potentiometric measurements at 20+/-0.5 deg C in 75percent (v/v) dioxane-water medium at various ionic strengths of sodium perchlorate.The method of Bjerrum and Calvin, as modified by Irving and Rossotti has been used to find out the values of n* (average number of ligand bound per metal ion) and pL (free ligand exponent).The formation constants of metal chelates have been computed on a PC-XT computer, using a program patterned after that of Sullivan et al. to give βn values using weighted least squares method.The Smin values (Smin = χ2) have been calculated.The order of formation constants of chelates was found to be: La3+ Ce3+ Pr3+ Nd3+ Sm3+ Eu3+ Gd3+ Y3+ Tb3+ Dy3+.The formation constants of the chelates formed have been correlated to size and ionization potentials of the metal ions. Keywords.Lanthanide metal ion; 2-Hydroxy-1-naphthaldehyde thiosemicarbazone (HNATS); Formation constant; Potentiometry.
Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects
Ahmed, Hany E. A.,El-Agrody, Ahmed M.,El-Araby, Moustafa E.,Ihmaid, Saleh,Mohamed, Hany M.,Mora, Ahmed,Omar, Abdelsattar M.,Bajorath, Jürgen
, (2020)
Thiazole derivatives are known to possess various biological activities such as antiparasitic, antifungal, antimicrobial and antiproliferative activities. Matrix metalloproteinases (MMPs) are important protease target involved in tumor progression includi
Aryl hydrazones linked thiazolyl coumarin hybrids as potential urease inhibitors
Salar, Uzma,Qureshi, Bakhtawer,Khan, Khalid Mohammed,Lodhi, Muhammad Arif,Ul?Haq, Zaheer,Khan, Farman Ali,Naz, Fouzia,Taha, Muhammad,Perveen, Shahnaz,Hussain, Shafqat
, p. 1221 - 1238 (2021/08/20)
Aryl hydrazones bearing thiazolyl coumarin hybrids 1–32 were prepared by following 'one-pot' two-steps reaction scheme. Various arylaldehydes were reacted to thiosemicarbazide under acidic condition to form aryl thiosemicarbazone intermediates which in turn treated with 3-bromoacetyl coumarin under basic condition to afford thiazolyl coumarin hybrids 1–32. All hybrids were recognized by EI- and HREI-MS and 1H- and 13C-NMR spectroscopic techniques. Compounds 1–32 were screened for in vitro inhibitory activity against urease enzyme and displayed good to moderate inhibitory potential in the ranges of IC50 = 16.29 ± 1.1–256.30 ± 1.4?μM. Worth stating that compound 21 (IC50 = 16.29 ± 1.1?μM) was identified as more potent urease inhibitor than the standard acetohydroxamic acid (IC50 = 27.0 ± 0.5?μM). Derivatives 19 (IC50 = 77.67 ± 1.5?μM) and 30 (IC50 = 71.21 ± 1.6?μM) were found to be moderately active. Structure–activity relationship revealed that -F, -Cl, -OH, and -OMe groups and their respective positions on aryl ring are playing important role in urease enzyme inhibition. Molecular docking studies identified important interaction between the ligand (active hybrids) and urease active site.
