1335093-53-2Relevant articles and documents
Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A
Zhang, Zhanbin,Lu, Xiaoxia,Xu, Jinbin,Rothfuss, Justin,MacH, Robert H.,Tu, Zhude
, p. 3986 - 3995 (2011/10/31)
A series of analogues were synthesized by optimizing the structure of papaverine. The in vitro PDE10A binding affinity (IC50) values for these new analogues were measured; for compounds that have IC50 value less than 60 nM for PDE10A