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18813-60-0

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18813-60-0 Usage

Uses

A metabolite of Papaverine (P190500).

Check Digit Verification of cas no

The CAS Registry Mumber 18813-60-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,1 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 18813-60:
(7*1)+(6*8)+(5*8)+(4*1)+(3*3)+(2*6)+(1*0)=120
120 % 10 = 0
So 18813-60-0 is a valid CAS Registry Number.

18813-60-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(6,7-dimethoxyisoquinolin-1-yl)methyl]-2-methoxyphenol

1.2 Other means of identification

Product number -
Other names 4-((6,7-dimethoxyisoquinolin-1-yl)methyl)-2-methoxyphenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18813-60-0 SDS

18813-60-0Relevant articles and documents

Natural Product Diversification by One-Step Biocatalysis using Human P450 3A4

Fessner, Nico D.,Grimm, Christopher,Srdi?, Matic,Weber, Hansj?rg,Kroutil, Wolfgang,Schwaneberg, Ulrich,Glieder, Anton

, (2021/12/03)

Efficient synthetic techniques for the diversification of natural products are incremental for drug discovery processes of the pharmaceutical industry because these complex bioactive compounds often require an adjustment of properties. Human liver P450 3A4, key player of the body's detoxification system and decisive factor of a drug's metabolic fate, is renowned for its broad substrate scope including many natural products. In this study, we investigated the synthetic potential of human P450 3A4 for the diversification of natural product classes and isolated the produced metabolites of six selected natural products at a preparative 100-mg scale. Aided by efficient expression levels in P. pastoris, this whole-cell biocatalyst was found to be highly effective at the intended job allowing the identification of a total of 31 authentic human metabolites, many of them for the first time. By revealing an unprecedented degree of diversification, this study extends the synthetic repertoire for efficient enzymatic natural product modification in a one-step fashion and adds a completely new view to an old enzyme traditionally used for inhibition and toxicology studies.

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A

Zhang, Zhanbin,Lu, Xiaoxia,Xu, Jinbin,Rothfuss, Justin,MacH, Robert H.,Tu, Zhude

, p. 3986 - 3995 (2011/10/31)

A series of analogues were synthesized by optimizing the structure of papaverine. The in vitro PDE10A binding affinity (IC50) values for these new analogues were measured; for compounds that have IC50 value less than 60 nM for PDE10A

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