133519-92-3

Upstream product

• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 1672-93-1 C₈H₉Cl₂N₅ 
• 134-81-6 benzil 

Downstream Products

• 1236224-79-5 2-imino-4-(2-chlorophenyl)-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-81-9 2-imino-4-(3-nitrophenyl)-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-80-8 2-imino-4-(2,4-dichlorophenyl)-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-74-0 2-imino-4-methyl-4-propyl-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-76-2 2-imino-8-(3,5-dichlorophenyl)-6,6-diphenyl-4-spirocyclopentanon-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-77-3 2-imino-4-(2-methylphenyl)-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-73-9 2-imino-4,4-dimethyl-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-75-1 2-imino-4-methyl-4-ethyl-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-78-4 2-imino-4-(3-methylphenyl)-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 
• 1236224-82-0 2-imino-4-(2-nitrostyryl)-8-(3,5-dichlorophenyl)-6,6-diphenyl-2,3-dihydro-4H-imidazo[2,3-d]-1,3,5-triazin-7(6H)one hydrochloride 

Relevant academic research and scientific papers

An efficient microwave-assisted synthesis of 6,8-dihydroimidazo[1,2-a] [1,3,5] triazine derivatives

(Chemical Equation Presented) A simple, efficient, and general method has been developed for the synthesis of various 4-substituted 2-amino-6,6-diphenyl- 8-aryl-6,8-dihydroimidazo[1,2-a] [1,3,5] triazine-7(4-H)ones 3a-3v. This involved condensation of 1-(5-oxo-4,4-diphenyl-1-aryl-4,5-dihydro-1H-imidazol-2- yl)guanidines 2a and 2b, themselves obtained from the reaction of aryl biguanides 1a/b with benzil, with the requisite carbonyl compounds. Both steps were performed using microwave heating in sealed vessels.

Reactions of Arylbiguanides with Benzoin at the pH of the Biguanide Bases

Arylbiguanides 2 a-e react with benzoin (1) at the pH of the base to two different products. 1 undergoes in presence of the base 2 a-e oxidation to benzil and benzoic acid, which reacts fast with the arylbiguanides 2 a-e to yield N-benzamides 3 a-d.After lowering the pH of the reacion mixture, the bases 2 b-e react with benzil to yield 2-guanidine 4 b-e.The mechanism of the formation is discussed.The structure of 4b was established from a single crystal x-ray structure analysis.The analysis was carried out at 100 K: C23H21N5O, Mr=383.5, monoclinic, C 2/c, a=15.842(6), b=8.419(3), c=30.223(10) Angstroem, β=98.44(3) deg, V=3987.3(9) Angstroem3, Z=8, dx=1.277 g/cm3, μ=0.81 cm-1, R=5.89percent, Rw=4.97percent (1537 observations, 233 parameters).Keywords.Benzoin, reaction with arylbiguanides; Triazines (N-benzamide); Imidazoles (2-guanidine); Synthesis; NMR-data; X-ray analysis.