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1335206-40-0

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1335206-40-0 Usage

General Description

Glycine, N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-N-(Methylsulfonyl)- is a chemical compound that is commonly used as a coupling reagent in peptide synthesis. It contains a glycine moiety, as well as a fluorenylmethoxycarbonyl (Fmoc) protecting group, an aminoethyl group, and a methylsulfonyl group. Glycine, N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-N-(Methylsulfonyl)- is often utilized in the production of peptides and has applications in pharmaceutical and biotechnology industries. Its unique structure makes it useful for enhancing the efficiency and specificity of peptide synthesis reactions. Additionally, it is known for its stability and low toxicity, making it a favorable choice for peptide synthesis processes.

Check Digit Verification of cas no

The CAS Registry Mumber 1335206-40-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,5,2,0 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1335206-40:
(9*1)+(8*3)+(7*3)+(6*5)+(5*2)+(4*0)+(3*6)+(2*4)+(1*0)=120
120 % 10 = 0
So 1335206-40-0 is a valid CAS Registry Number.

1335206-40-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethyl)-N-(methylsul fonyl)glycine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1335206-40-0 SDS

1335206-40-0Downstream Products

1335206-40-0Relevant articles and documents

Bioactivity improvement via display of the hydrophobic core of HYD1 in a cyclic β-hairpin-like scaffold, MTI-101

Jain, Priyesh,Badger, David B.,Liang, Yi,Gebhard, Anthony W.,Santiago, Daniel,Murray, Philip,Kaulagari, Sridhar R.,Gauthier, Ted J.,Nair, Rajesh,Kumar, MohanRaja,Guida, Wayne C.,Hazlehurst, Lori A.,McLaughlin, Mark L.

, (2021)

HYD1 is an all D-amino acid linear 10-mer peptide that was discovered by one-bead-one-compound screening. HYD1 has five hydrophobic amino acids flanked by polar amino acids. Alanine scanning studies showed that alternating hydrophobic amino acid residues and N- and C-terminal lysine side chains were contributors to the biological activity of the linear 10-mer analogs. This observation led us to hypothesize that display of the hydrophobic pentapeptide sequence of HYD1 in a cyclic beta-hairpin-like scaffold could lead to better bioavailability and biological activity. An amphipathic pentapeptide sequence was used to form an antiparallel strand and those strands were linked via dipeptide-like sequences selected to promote β-turns. Early cyclic analogs were more active but otherwise mimicked the biological activity of the linear HYD1 peptide. The cyclic peptidomimetics were synthesized using standard Fmoc solid phase synthesis to form linear peptides, followed by solution phase or on-resin cyclization. SAR studies were carried out with an aim to increase the potency of these drug candidates for the killing of multiple myeloma cells in vitro. The solution structures of 1, 5, and 10 were elucidated using NMR spectroscopy. 1H NMR and 2D TOCSY studies of these peptides revealed a downfield Hα proton chemical shift and 2D NOE spectral analysis consistent with a β-hairpin-like structure.

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