133522-40-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Production:
(2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL is utilized as a key component in the production of various pharmaceuticals and agrochemicals. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which is crucial for ensuring the desired biological activity and minimizing potential side effects.
Used in Asymmetric Synthesis:
In the field of organic chemistry, (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL serves as a chiral auxiliary for asymmetric synthesis. It is employed to control the stereochemical outcome of reactions, leading to the preferential formation of one enantiomer over another. This selective synthesis is vital for producing enantiomerically pure compounds with specific biological activities and properties.
Used in Medical Research:
(2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL has been the subject of medical research for its potential therapeutic applications. Studies have investigated its use in the treatment of hypertension and arrhythmias, highlighting its potential as a novel therapeutic agent for cardiovascular conditions.

Upstream product

• 929548-38-9 (2R,3R,3aS,6R,6aR,3'R,3'aS,6'R,6'aR,5''R)-spiro[6,3',6'-trihydroxy-octahydro[2,3']bi[furo[3,2-b]furan]-3,2''-[5''-phenoxymethyl-1'',3''-oxazolidine]] 
• 86809-23-6 l-1-Phenoxy-2-hydroxy-3-ammoniumpropane-L-pantoate 
• 86809-23-6 d-1-Phenoxy-2-hydroxy-3-ammoniumpropane-D-pantoate 
• 140428-47-3 Acetic acid 1-bromomethyl-2-phenoxy-ethyl ester 
• 140630-34-8 (S)-1-chloro-2-acetoxy-3-phenoxypropane 
• 140630-39-3 (S)-3-bromo-1-phenoxy-2-propanol 
• 122-60-1 Phenyl glycidyl ether 
• 71031-03-3 (2R)-1,2-epoxy-3-phenoxypropane 
• 140630-37-1 (2R)-1-azido-3-phenoxypropan-2-ol 
• 4769-73-7 (RS)-1-chloro-3-phenyloxy-2-propanol 

Downstream Products

• 1630042-69-1 C₂₈H₂₃ClN₆O₃S 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of new macrolide scaffolds with activities against resistant pathogens is urgently needed. An efficient method for reconstructing the erythromycin A macrolactone skeleton has been established. Based on this methodology, novel 15-membered macrolides, known as '11a-azalides', with substituents at the C12, C13, or C4″ positions were synthesized and their antibacterial activities were evaluated. These derivatives showed promising antibacterial activities against erythromycin-resistant Streptococcus pneumoniae. Among them, the C4″ substituted derivatives had the most potent activity against erythromycin-resistant S. pneumoniae.

Non-enzymatic kinetic resolution of β-amino alcohols using C-12 higher carbon sugar as a chiral auxiliary

An efficient non-enzymatic kinetic resolution strategy capable of accessing optically active β-adrenergic antagonists intermediates is reported. The C-12 higher carbon sugar derived from naturally occurring sucrose was employed to probe the kinetic resolution. Excellent enantiomeric excesses (ee >99%) and high yields were obtained under very mild conditions. The chiral auxiliary could be recovered in a high reclaimed ratio (>95%) and reusable form without any decrease of the resolving ability.

Resolution of β-aminoalcohols and 1,2-diamines using fractional crystallization of diastereomeric salts of dehydroabietic acid

(S)-(+)-1-Amino-3-phenyloxy-2-propanol, (R)-(-)-2-amino-1-phenylethanol, (S)-(+)-1-amino-2-propanol, (1S,2S)-(+)-2-aminocyclohexanol and (1S,2S)-(+)-1,2-diaminocyclohexane were resolved using dehydroabietic acid. It was shown that good to high enantiomeric purity, between 81～>99% ee, was obtained and that dehydroabietic acid could be easily and efficiently recovered in a reusable form.

Enzyme Assisted Preparation of Enantiomerically Pure β-Adrenergic Blockers II. Building Blocks of High Optical Purity and their Synthetic Conversion

Based on previous screening results a series of potential building blocks 2-4 for β-adrenergic blockers were prepared both by enzymatic hydrolysis and acyltransfer and further transformed into the corresponding oxiranes and aminoalcohols of defined absolu