4769-73-7

Basic information

• Product Name: 1-chloro-3-phenoxypropan-2-ol
• Synonyms: 1-chloro-3-phenoxypropan-2-ol;1-Chloro-3-phenoxy-2-propanol;1-Chloro-3-phenoxypropane-2-ol;1-Phenoxy-3-chloro-2-propanol;1-Phenoxy-3-chloropropane-2-ol;3-Chloro-1-phenoxy-2-propanol;1-Chloro-2-hydroxy-3-phenoxypropane;2-Propanol, 1-chloro-3-phenoxy-
• CAS NO: 4769-73-7
• Molecular Formula: C₉H₁₁ClO₂
• Molecular Weight: 186.63544
• EINECS: 225-310-5
• Mol File: 4769-73-7.mol
• Article Data: 62

Chemical Properties

• Boiling Point: 309.8°C at 760 mmHg
• Flash Point: 141.2°C
• Appearance: /
• Density: 1.198g/cm³
• Vapor Pressure: 0.000269mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 1-chloro-3-phenoxypropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-3-phenoxypropan-2-ol(4769-73-7)
• EPA Substance Registry System: 1-chloro-3-phenoxypropan-2-ol(4769-73-7)

Safety Data

• Hazardous Substances Data: 4769-73-7(Hazardous Substances Data)

Usage

Uses

1-chloro-3-phenoxypropan-2-ol (cas# 4769-73-7) is used as a promoter for for cross linking of epoxy resins with primary amines.

InChI:InChI=1/C9H11ClO2/c10-6-8(11)7-12-9-4-2-1-3-5-9/h1-5,8,11H,6-7H2

Upstream product

• 110-86-1 pyridine 
• 106-89-8 epichlorohydrin 
• 108-95-2 phenol 
• 79-35-6 1,1'-dichloro-2,2'-difluoroethene 
• 122-60-1 Phenyl glycidyl ether 
• 506-59-2 N,N-dimethylammonium chloride 
• 940-47-6 1-chloro-3-phenoxyacetone 
• 762-72-1 allyl-trimethyl-silane 
• 538-43-2 3-phenoxy-1,2-propanediol 
• 1746-13-0 allyl phenyl ether 
• 68-12-2 N,N-dimethyl-formamide 
• 71031-03-3 (R)-phenyl glycidyl ether 
• 122-97-4 3-Phenyl-1-propanol 
• 140630-45-1 (R)-1-chloro-3-phenoxy-2-propanol 

Downstream Products

• 49659-09-8 1-(2-hydroxy-3-phenoxy-propyl)-pyridinium; chloride 
• 76210-92-9 1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-3-phenoxy-propan-2-ol; hydrochloride 
• 140924-05-6 (R)-2-acetoxy-1-phenoxy-3-chloropropane 
• 140630-34-8 (S)-1-chloro-2-acetoxy-3-phenoxypropane 
• 622-04-8 1,3-diphenoxy-2-propanol 
• 140630-45-1 (R)-1-chloro-3-phenoxy-2-propanol 
• 82430-43-1 (S)-3-chloro-1-phenoxy-2-propanol 
• 140630-44-0 2-butyloxy-1-chloro-3-phenoxypropan 
• 946528-29-6 1-phenoxy-3-thiocyanatopropan-2-one 
• 77216-37-6 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-phenoxy-2-propanol 
• 71031-03-3 (R)-phenyl glycidyl ether 
• 140630-43-9 (2R)-1-Isopropylamino-3-phenoxy-2-propanol 
• 106351-44-4 (2S)-1-Isopropylamino-3-phenoxy-2-propanol 
• 133522-40-4 (R)-(-)-1-amino-3-phenyloxy-2-propanol 

Relevant articles and documents

A phosphonium ylide as a visible light organophotoredox catalyst

A phosphonium ylide-based visible light organophotoredox catalyst has been designed and successfully applied to halohydrin synthesis using trichloroacetonitrile and epoxides. An oxidative quenching cycle by the ylide catalyst was established, which was confirmed by experimental mechanistic studies.

Synthesis, Characterization, and Evaluation of Surface and Thermal Properties and Cytotoxicity of 2-Hydroxy-3-Phenoxypropyl Imidazolium Bola-Type Gemini Amphiphiles

A library of imidazolium-based gemini cationic bola amphiphiles was synthesized using a regioselective ring-opening reaction of glycidyl phenyl ether with imidazole under solvent-free conditions. The corresponding hexafluorophosphate (PF6?) and tetrafluoroborate (BF4?) counterion-containing amphiphiles were also synthesized and characterized using nuclear magnetic resonance (NMR) and mass spectroscopy. The micellar and interfacial parameters like the critical micelle concentration (CMC), surface pressure at the CMC (Пcmc), surface tension at CMC (γcmc), counterion binding (β), maximum surface excess concentration (Γmax), minimum area per molecule (Amin), standard free energy of micellization (ΔG0mic) and adsorption (ΔG0ads), and Kraft temperature were evaluated using surface tension and conductometry methods in aqueous solution as well as in buffer solution. Dynamic light scattering (DLS) was used to determine the size of the micelles formed in the aqueous solution. Cytotoxicity tests were carried out on the C6 glioma cancerous brain cell line using the MTT assay (3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazolium bromide) to evaluate the IC50 value of all the synthesized amphiphiles. Thermal stability of these amphiphiles was also evaluated using a thermal gravimetric analyzer (TGA). Economic way of synthesis, moderate thermal stability, a low value of CMC, and cytotoxicity of these amphiphiles will inspire new research in the field of nanobiotechnology and pharmaceutical industries.

Highly enantioselective CALB-catalyzed kinetic resolution of building blocks for β-blocker atenolol

Both enantiomers of 4-(3-chloro-2-hydroxypropoxy)phenyl)acetamide has been synthesized in 98.5–99% enantiomeric excess by use of lipase B from Candida antarctica as catalyst. The R-alcohol is a building block for the cardioselective β-blocker (S)-atenolol ((S)-2-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide. Performing kinetic resolutions of 3-chloro-1-phenoxy-2-propanol and 3-bromo-1-phenoxy-2-propanol with vinyl butanoate as acyl donor and the same CALB enzyme, but a different preparation, showed higher E-values than previously reported.