133523-40-7Relevant articles and documents
Studies on the chemistry of rapamycin: Novel transformations under Lewis-acid catalysis
Luengo,Konialian,Holt
, p. 991 - 994 (2007/10/02)
The reactivity of rapamycin under mild Lewis-acid catalysis has been investigated. The molecule has been found to be extremely sensitive to basic reagents due to carboxylate elimination β to the C24 ketone. However, transformations normally eff
On the Remarkable Propensity for Carbon-Carbon Bond Cleavage Reactions in the C8-C10 Region of FK-506
Fisher, Matthew J.,Chow, Ken,Villalobos, Anabella,Danishefsky, Samuel J.
, p. 2900 - 2907 (2007/10/02)
It has been deduced from a series of transformations that formation of a tetrahedral intermediate at C9 in FK-506 occasions fragmentation of the C9-C10 bond by a retro-Claisen-like pathway or the C9-C8 bond by a benzilic acid type rearrangement.Reduction