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Upstream product

• 591227-12-2 2-phenylimidazo[1,2-a]pyrimidin-7-amine 
• 130187-88-1 2-[1-(dimethylamino)methylidene]-3-oxosuccinic acid diethyl ester 
• 81303-67-5 5-chlorocarbonyl-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 81303-65-3 4-(ethoxycarbonyl)-1-methyl-1H-pyrazole-5-carboxylic acid 
• 10514-61-1 2-methyl-2H-pyrazole-3,4-dicarboxylic acid diethyl ester 
• 70-11-1 α-bromoacetophenone 

Relevant academic research and scientific papers

IMIDAZOPYRIMIDINE DERIVATIVES

The invention is concerned with novel imidazopyrimidine derivatives of formula (I) wherein R1, R2 and R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.

N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS

The invention is concerned with novel imidazopyrimidine derivatives of formula (I) wherein R1, R2 and R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDEIOA and used as medicaments.