1335386-74-7

Basic information

• Product Name: methyl 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-3-carboxylate
• Synonyms: methyl 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-3-carboxylate
• CAS NO: 1335386-74-7
• Molecular Weight: 654.781
• Mol File: 1335386-74-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-3-carboxylate(1335386-74-7)
• EPA Substance Registry System: methyl 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-3-carboxylate(1335386-74-7)

Safety Data

• Hazardous Substances Data: 1335386-74-7(Hazardous Substances Data)

Upstream product

• 1335387-24-0 C₁₉H₃₁IN₂O₃ 
• 63-91-2 L-phenylalanine 
• 113850-76-3 N-(tert-butoxycarbonyl)-4-iodo-L-phenylalanine methyl ester 
• 1335387-28-4 C₂₆H₃₅IN₂O₇S 
• 99769-19-4 [3-(methoxycarbonyl)phenyl]boronic acid 
• 1335387-25-1 C₂₆H₃₇IN₂O₆S 
• 1335387-19-3 C₁₅H₂₁ClINO₃ 
• 1335387-17-1 C₁₅H₁₉ClINO₃ 

Relevant articles and documents

Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors

A series of P1-substituted biaryl amprenavir derivatives was designed and synthesized. These compounds were evaluated for enzyme inhibition and antiviral activity in vitro. Several compounds showed highly efficient antiviral activity with EC50 values down to 0.10 nM, which are more potent than marketed HIV-1 protease inhibitors. Docking study indicated that 12c has similar binding mode to amprenavir with full occupancy in P1.